Marcus Järås

The 3D genome of pediatric B-cell precursor acute lymphoblastic leukemia

Larissa Helena Moura‐Castro, Efe Aydın, Gladys Telliam Dushime, Eleanor L. Woodward et autres

Abstract Whereas the molecular pathogenesis of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) has been studied extensively, its 3D chromatin landscape – of vast importance for gene regulation – remains poorly explored. Here, we applied Micro-C, a high-resolution variant of Hi-C, …

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H2-K1 protects murine MLL-AF9 leukemia stem cells from natural killer cell-mediated immune surveillance

Somadri Ghosh, Maria Rodriguez‐Zabala, Gladys Telliam Dushime, Katrin Reinbach et autres

Not available.

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Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment

Nils Hansen, Pablo Peña‐Martínez, Petter Skoog, Katrin Reinbach et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) represents a major clinical challenge due to its tumor microenvironment, which exhibits immune-suppressive properties that facilitate cancer progression, metastasis, and therapy resistance. Interleukin 1 (IL-1) signaling has been implicated as a driver in this process. Mechanistically, both …

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Targeting Cholesterol Homeostasis Enhances Phagocytosis of Acute Myeloid Leukemia Cells

Somadri Ghosh, Katrin Reinbach, Pablo Peña‐Martínez, Ramprasad Ramakrishnan et autres

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and is associated with poor outcome. While allogeneic stem cell transplantation can be curative, it is often accompanied by severe side-effects. Recently, there has been emerging recognition that …

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3068 – CRISPR SCREENING IN PRIMARY HUMAN CD34+ HEMATOPOIETIC STEM AND PROGENITOR CELLS IDENTIFIES THE RNA HELICASE DDX6 AS A NOVEL HSC REGULATOR

Hanna Maria Eriksson, Alexandra Bäckström, Tyra Bremborg, Kristijonas Žemaitis et autres

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Abstract 2895: ILRAP blockade mediates anti-fibrotic effects in pancreatic cancer-associated fibroblasts

Neel Ingemann Nissen, Nils Hansen, Elin Jaensson Gyllenbäck, Camilla Rydberg Millrud et autres

Abstract Introduction: Pancreatic cancer (PDAC) patients have poor prognosis partly due to excessive activity of cancer-associated fibroblasts (CAFs). CAFs drive the fibrosis that causes excessive type III collagen and extracellular matrix deposition that in turn reduces drug response resulting in poor survival. …

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The 3D Chromatin Landscape of B-Cell Precursor Childhood Acute Lymphoblastic Leukemia

Larissa Helena Moura‐Castro, Minjun Yang, Eleanor L. Woodward, Anders Castor et autres

Whilst the molecular pathogenesis of childhood B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) has been studied extensively, its 3D chromatin landscape remains poorly explored. Genome-wide chromosome conformation capture methods have provided the tools to investigate the different units of chromatin organization, such …

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Targeting SLC3A2 Sensitizes AML Cells Towards NK Cell-Mediated Killing

Kishan Bellamkonda, Ramprasad Ramakrishnan, Somadri Ghosh, Katrin Reinbach et autres

Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis; hence, new therapeutic strategies are urgently needed. Natural Killer (NK) cells play a key role in tumor immune surveillance, but their anti-tumor activity in AML is often attenuated due to …

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H2-K1 on MLL-AF9 Leukemia Cells Facilitates the Escape of NK Cell-Mediated Immune Surveillance

Somadri Ghosh, Maria Rodriguez Zabala, Gladys Telliam Dushime, Katrin Reinbach et autres

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, and prognosis is poor; 5-year survival approximately 30%. Recently, there is an emerging recognition of the innate immune system, in particular Natural killer (NK) cells and macrophages, for …

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Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity

Maria Rodriguez‐Zabala, Ramprasad Ramakrishnan, Katrin Reinbach, Somadri Ghosh et autres

Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo …

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Skin mesenchymal niches maintain and protect AML-initiating stem cells

Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao et autres

Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin …

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Table S6 from In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets

Elsa Arbajian, Florian Puls, Cristina R. Antonescu, Fernanda M Amary et autres

Expression of the SEF vs controls 100-top up-regulated genes in Tet-On 3G cells expressing the EWSR1-CREB3L1 fusion