Accès ouvert
2018
preprint
OpenAlex
Elisa Pantano, Sara Marchi, Massimiliano Biagini, Martina Di Fede et autres
Abstract Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein and a component of the Bexsero vaccine. NHBA is characterized by the presence of a highly conserved Arg-rich region involved in binding to heparin and heparin sulphate proteoglycans present on the surface …
be
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Accès ouvert
2016
article
OpenAlex
Luigi Scietti, Katia Sampieri, Irene Pinzuti, Erika Bartolini et autres
During bacterial pathogenesis extensive contacts between the human and the bacterial extracellular proteomes take place. The identification of novel host-pathogen interactions by standard methods using a case-by-case approach is laborious and time consuming. To overcome this limitation, we took advantage of large …
it, ch
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Accès ouvert
2016
article
OpenAlex
Luigi Fiaschi, Benedetta Di Palo, Maria Scarselli, Clarissa Pozzi et autres
Staphylococcus aureus alpha-hemolysin (Hla) assembles into heptameric pores on the host cell membrane, causing lysis, apoptosis, and junction disruption. Herein, we present the design of a newly engineered S. aureus alpha-toxin, HlaPSGS, which lacks the predicted membrane-spanning stem domain. This protein is …
us
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Accès ouvert
2015
article
OpenAlex
Fábio Bagnoli, Maria Rita Fontana, Elisabetta Soldaini, Ravi P.N. Mishra et autres
Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt to develop an effective S. aureus vaccine, we selected five conserved antigens known to have different roles in S. aureus pathogenesis. …
ch, it, us
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Accès ouvert
2014
article
OpenAlex
Giuseppe Bozza, Mirco Capitani, Paolo Montanari, Barbara Benucci et autres
Neisseria meningitidis adhesin A (NadA) is a meningococcus surface protein thought to assist in the adhesion of the bacterium to host cells. We have previously shown that NadA also promotes bacterial internalization in a heterologous expression system. Here we have used the …
it
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Accès ouvert
2014
article
OpenAlex
Kai Y. Xu, Zhuhao Wu, Nicolas Renier, Alexander Antipenko et autres
Netrins are secreted proteins that regulate axon guidance and neuronal migration. Deleted in colorectal cancer (DCC) is a well-established netrin-1 receptor mediating attractive responses. We provide evidence that its close relative neogenin is also a functional netrin-1 receptor that acts with DCC …
us
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Accès ouvert
2014
article
OpenAlex
Marilena Gallotta, Giovanni Gancitano, Giampiero Pietrocola, Marirosa Mora et autres
Group A streptococcus (GAS) is a human pathogen causing a wide repertoire of mild and severe diseases for which no vaccine is yet available. We recently reported the identification of three protein antigens that in combination conferred wide protection against GAS infection …
it
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2013
article
OpenAlex
Christina Schluepen, E. Malito, Ambra Marongiu, Markus Schirle et autres
In the human pathogen Staphylococcus aureus, there exists an enormous diversity of proteins containing DUFs (domains of unknown function). In the present study, we characterized the family of conserved staphylococcal antigens (Csa) classified as DUF576 and taxonomically restricted to Staphylococci. The 18 …
it, us, ch
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Accès ouvert
2012
article
OpenAlex
Daniele Veggi, Maria Antonietta Gentile, Francesca Cantini, Paola Lo Surdo et autres
The factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis that confers to the bacterium the ability to resist killing by human serum. The determination of its three-dimensional structure revealed that the carboxyl terminus of the protein folds …
it
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2012
article
OpenAlex
Paolo Mariotti, E. Malito, Marco Biancucci, Paola Lo Surdo et autres
Staphylococcus aureus is a human pathogen causing globally significant morbidity and mortality. The development of antibiotic resistance in S. aureus highlights the need for a preventive vaccine. In the present paper we explore the structure and function of FhuD2 (ferric-hydroxamate uptake D2), …
it, us
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Accès ouvert
2012
article
OpenAlex
Marta Castagnini, Monica Picchianti, Eleonora Talluri, Massimiliano Biagini et autres
Among the several toxins used by pathogenic bacteria to target eukaryotic host cells, proteins that exert ADP-ribosylation activity represent a large and studied family of dangerous and potentially lethal toxins. These proteins alter cell physiology catalyzing the transfer of the ADP-ribose unit …
it
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Accès ouvert
2011
article
OpenAlex
Francesca Necchi, Vincenzo Nardi‐Dei, Massimiliano Biagini, Michael Assfalg et autres
Streptococcus agalactiae, also referred to as Group B Streptococcus (GBS), is one of the most common causes of life-threatening bacterial infections in infants. In recent years cell surface pili have been identified in several Gram-positive bacteria, including GBS, as important virulence factors …
it
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