Daniel Tornero

Reorganization of Burst Initiation Zones as a Signature of Stimulation-Induced Plasticity in In Vitro Cortical Networks

Mikel Ocio-Moliner, Anna-Christina Haeb, Akke Mats Houben, Daniel Tornero et autres

The dynamics of the initiation and propagation of these bursts are believed to depend on the structural connectivity of the neuronal network. Specifically, the spatial loci of burst initiation, referred to as initiation zones (IZs), are shaped by a complex interplay between …

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The gut–brain axis: mechanisms linking intestinal dysbiosis with stroke

José Tomás Garrido Santos, Daniel Tornero, Marie Karam

Gut microbiota has emerged as a key regulator of immune, metabolic, and neuroinflammatory processes, exerting significant influence on central nervous system (CNS) function via the gut-brain axis. Growing evidence suggests that gut dysbiosis not only precedes and worsens stroke severity but is …

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Protocol for tailored in vitro neuronal networks on high-density microelectrode arrays with polydimethylsiloxane microstructures

Anna-Christina Haeb, Hideaki Yamamoto, Paul Roach, Daniel J. Merryweather et autres

Complementary metal-oxide-semiconductor (CMOS)-based high-density microelectrode arrays (HD-MEAs) enable neuronal recordings with high spatiotemporal resolution. However, integrating polydimethylsiloxane (PDMS) microstructures onto HD-MEA surfaces to control network architecture is currently challenging and platform specific. Here, we present a protocol for PDMS fabrication, HD-MEA chip …

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Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning

Isabel Turpin-Moreno, Adriana Modrego, Andrea Martí-Sarrias, Laura García‐González et autres

gene. Brain organoids (BOs) have emerged as reliable models for neurodevelopmental genetic disorders, reproducing human brain developmental milestones and rising as a promising drug testing tool. Here, we determined the underlying molecular DS pathophysiology affecting neuronal connectivity, revealing an early onset excitatory-inhibitory …

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Cortico-Hippocampal Assembloids: A Novel Tool for Studying Alzheimer's Disease

Alba Gascó, Clàudia Puigsasllosas Pastor, Valérie Petegnief, Daniel Tornero

Trabajo presentado en el XX Meeting of the Spanish Society for Neuroscience, celebrado en Las Palmas de Gran Canaria (Españ), del 3 al 5 de septiembre de 2025

BDNF Overexpression Enhances Neuronal Activity and Axonal Growth in Human iPSC-Derived Neural Cultures

Alba Ortega-Gascó, Francesca Percopo, Ares Font-Guixe, Santiago Ramos-Bartolome et autres

As the global population continues to age, the incidence of neurodegenerative diseases and neural injuries is increasing, presenting major challenges for healthcare systems. Due to the brain's limited regenerative capacity, there is an urgent need for strategies that promote neuronal repair and …

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Emerging Insights into Brain Inflammation: Stem-Cell-Based Approaches for Regenerative Medicine

Marie Karam, Alba Ortega-Gascó, Daniel Tornero

Neuroinflammation is a complex immune response triggered by brain injury or pathological stimuli, and is highly exacerbated in neurodegenerative diseases. It plays a dual role in the central nervous system, promoting repair in acute stages while aggravating disease progression by contributing to …

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Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

Isabel Turpin-Moreno, Adriana Modrego, Andrea Martí-Sarrias, Anna-Christina Haeb et autres

ABSTRACT Brain organoids (BO) have risen as a reliable model for neurodelopmental disorders (ND), reproducing human brain development milestones. However, their significant intra- and inter-organoid variability compromises their use in advanced tasks such as drug testing. Overcoming experimental variability is crucial for …

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Updated Toolbox for Assessing Neuronal Network Reconstruction after Cell Therapy

Ana Gonzalez‐Ramos, Claudia Puigsasllosas-Pastor, Ainhoa Arcas-Marquez, Daniel Tornero

Cell therapy has proven to be a promising treatment for a range of neurological disorders, including Parkinson Disease, drug-resistant epilepsy, and stroke, by restoring function after brain damage. Nevertheless, evaluating the true effectiveness of these therapeutic interventions requires a deep understanding of …

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Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease

Ened Rodríguez-Urgellés, Diana Casas-Torremocha, Anna Sancho‐Balsells, Iván Ballasch et autres

BACKGROUND: Huntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum is a major hallmark of the disease. Approximately 30% of those glutamatergic inputs come from thalamic nuclei. Foxp2 is a transcription factor involved in cell …

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Hyaluronic acid-based bioink improves the differentiation and network formation of neural progenitor cells

Inês Pereira, Maria Jose Lopez-Martinez, Aránzazu Villasante, Clelia Introna et autres

Introduction: Three-dimensional (3D) bioprinting is a promising technique for the development of neuronal in vitro models because it controls the deposition of materials and cells. Finding a biomaterial that supports neural differentiation in vitro while ensuring compatibility with the technique of 3D …

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First Organoid Intelligence (OI) workshop to form an OI community

Itzy E. Morales Pantoja, Lena Smirnova, Alysson Renato Muotri, Karl J. Wahlin et autres

The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of power. The human …

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