Tom Holland

rth

Tom Holland

rth

Tom Holland

Immature teratomas remain difficult to diagnose: A cross-sectional study

S.A. Mitchell, Jonathan Gaughran, Tom Holland, Ahmad Sayasneh

Background & Objectives: The ultrasound features of ovarian mature teratomas are well defined. However, literature regarding the ultrasound features of immature teratomas is lacking and features can often be confused with those of mature teratomas. The objective of this study was to …

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Diagnosis of superficial endometriosis on transvaginal ultrasound by visualization of peritoneum of pouch of Douglas

F. Amos Bailey, Jonathan Gaughran, Siobhan B. Mitchell, Caroline Ovadia et autres

OBJECTIVE: Around 80% of women with endometriosis have superficial endometriosis (SE) rather than ovarian or deep endometriosis (DE). However, to date, advances in non-invasive, imaging-based diagnosis have been limited to DE or ovarian disease. The objective of this study was to determine …

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Effectiveness of laparoscopic removal of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women (ESPriT2): protocol for a multi-centre randomised controlled trial

Scott C. Mackenzie, Jacqueline Stephen, Linda Jane Williams, JANE P. DANIELS et autres

BACKGROUND: Endometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis is often achieved through diagnostic laparoscopy. However, when isolated superficial peritoneal endometriosis (SPE), the most common …

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O-141 Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial

Andrew W. Horne, Stephen Y. C. Tong, Catherine A Moakes, Lee Middleton et autres

Abstract Study question Is a combination of parenteral methotrexate and oral gefitinib more effective than methotrexate alone in the treatment of tubal ectopic pregnancy? Summary answer In women with a tubal ectopic pregnancy, adding oral gefitinib to parental methotrexate does not offer …

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Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT

Catherine A Moakes, Stephen Y. C. Tong, Lee Middleton, William Colin Duncan et autres

Background Tubal ectopic pregnancies can cause significant morbidity or even death. Current treatment is with methotrexate or surgery. However, methotrexate treatment can fail in approximately 30% of women. Gefitinib, an epidermal growth factor receptor inhibitor, may improve the effects of methotrexate. We …

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Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial

Andrew W. Horne, Stephen Y. C. Tong, Catherine A Moakes, Lee Middleton et autres

BACKGROUND: Tubal ectopic pregnancies can cause substantial morbidity or even death. Current treatment is with methotrexate or surgery. Methotrexate treatment fails in approximately 30% of women who subsequently require rescue surgery. Gefitinib, an epidermal growth factor receptor inhibitor, might improve the effects …

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The impact of the Covid-19 pandemic on care of women with ectopic pregnancy in a tertiary London hospital

Jonathan Gaughran, Dorothea Geddes‐Barton, Tom C. Lyne, Frances Bailey et autres

BACKGROUND: In response to the COVID-19 pandemic, a central London tertiary referral hospital's nurse-led Early Pregnancy & Acute Gynaecology Unit (EPAGU) suspended its walk-in service in favour of a telephone triage system with scheduled appointments. OBJECTIVE: To assess if the pandemic and …

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VP01.07: The pregnancy outcomes of tubal and ovarian heterotopic pregnancies

S.A. Solangon, Mohamed Otify, Jonathan Gaughran, Tom Holland et autres

Studies on heterotopic pregnancies have reported widely varying rates of miscarriage and live-birth rates of normally sited (eutopic) pregnancies. The aim of our study was to examine the risk of miscarriage of the live eutopic pregnancy following the treatment of concomitant ectopic …

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OC06.05: Conservative versus medical management of retained products of conception

Siobhan B. Mitchell, Jonathan Gaughran, Caroline Ovadia, Jasmine Kuah et autres

Retained products of conception (RPOC) are defined as the persistence of pregnancy tissue within the uterine cavity following delivery, miscarriage or termination of pregnancy. It is associated with persistent PV bleeding, lower abdominal pain, infection and long term sequaele such as intrauterine …

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Re: Laparoscopic cornual resection of interstitial pregnancy using the Endo GIATM Universal Stapler

Maximilian Brincat, Tom Holland, Joel Naftalin, D. Jurkovic

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