Scott Richards

Sequencing and health data resource of children of African ancestry

Leah C. Kottyan, Scott Richards, Morgan E Tracy, Lucinda P. Lawson et autres

Purpose Individuals who self-report as Black or African American are historically underrepresented in genome-wide studies of disease risk, a disparity particularly evident in pediatric disease research. To address this gap, Cincinnati Children's Hospital Medical Center (CCHMC) established a biorepository and developed a …

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Accuracy of the Scaled Flux Method for Spatially Resolved Nuclide Transmutation in Flowing-Fuel Molten Salt Reactors

Luke Seifert, Shayan Shahbazi, Scott Richards, Madicken Munk et autres

Depletion simulations of flowing-fuel molten salt reactors do not typically distinguish between the in-core and ex-core regions. Instead, they either irradiate the entire primary loop while scaling the flux, or irradiate the in-core volume alone, which leaves some amount of fuel salt …

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Infrastructure and resource development needs to support a significant expansion of US nuclear capacity

Levi Morin Larsen, Scott Richards, Taek K. Kim, Eva E. Davidson et autres

In December 2023, the United States pledged at a United Nations conference to triple nuclear energy by 2050. In May of 2025 a new administration announced plans to quadruple nuclear energy by 2025, setting a new target that requires understanding the key …

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Initial Benchmark Comparison of the Open-Source Cyclus and NMB Fuel Cycle Simulators

Amanda M. Bachmann, Kenji Nishihara, Scott Richards, Takumi Abe et autres

Verification exercises between fuel cycle simulators are important for understanding how the methodology and capability differences between the simulators affect the results.This work performs an initial verification exercise with the Cyclus and NMB fuel cycle simulators.The exercise compares the results of the …

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Author response: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall et autres

eLife AssessmentThis interesting study presents important information on how human cytomegalovirus (HCMV) infection disrupts the activity of the TEAD1 transcription factor, leading to widespread chromatin alterations.The strength of evidence in revised manuscript is convincing, and includes additional functional data teasing out how …

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Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall et autres

Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hr after infection. Integrative analyses …

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Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall et autres

Summary Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hours after infection. Integrative …

us (code pays fourni par la source)

Author response: Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall et autres

Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hours after infection. Integrative analyses …

Sequencing and health data resource of children of African ancestry

Leah Claire Kottyan, Scott Richards, Lucinda P. Lawson, Beth L. Cobb et autres

Abstract Purpose Individuals who self-report as Black or African American are historically underrepresented in genome-wide studies of disease risk, a disparity particularly evident in pediatric disease research. To address this gap, Cincinnati Children’s Hospital Medical Center (CCHMC) established a biorepository and developed …

us, au (code pays fourni par la source)

Infrastructure and Resource Development Needs to Support Tripling of Us Nuclear Capacity

Levi Morin Larsen, Scott Richards, Taek‐Kyun Kim, Eva E. Davidson et autres

us (code pays fourni par la source)

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall et autres

Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hr after infection. Integrative analyses …

us (code pays fourni par la source)

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Khund Sayeed, Sreeja Parameswaran, Matthew J. Beucler, Lee Edsall et autres

Abstract Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hours after infection. Integrative …

us (code pays fourni par la source)