Accès ouvert
2026
preprint
OpenAlex
Anna Yui, Liyi Peng, Katie C. Lew, Dylan J. Landau et autres
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that accounts for nearly 20% of breast cancer diagnoses. Despite recent approvals of novel therapeutic agents for TNBC, neoadjuvant chemotherapy remains part of standard of care treatment for TNBC patients. …
us
(code pays fourni par la source)
Accès ouvert
2025
supplementary-materials
OpenAlex
Glenn J. Hanna, Scott A. Roof, James Jabalee, Eleni M. Rettig et autres
Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance
Accès ouvert
2025
erratum
OpenAlex
Gat Rauner, Nicole Traugh, Colin J. Trepicchio, Meadow E. Parrish et autres
There were errors in Development (2025) 152, dev204813 (doi:10.1242/dev.204813).The authors contacted us to say that there were three incorrectly cited references. The updated citations are detailed below.In the first paragraph of the ‘Results: Regeneration, architecture and patterning of patient-derived organoids from single …
2025
article
OpenAlex
Gat Rauner, Nicole Traugh, Colin J. Trepicchio, Meadow E. Parrish et autres
Current breast organoid models, primarily based on self-assembly, face limitations in accurately mimicking the complex stages of tissue development, notably in replicating detailed tissue architectures and cellular diversity. Here, we demonstrate that a solitary human breast stem cell can, within a controlled …
us
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Accès ouvert
2025
preprint
OpenAlex
Hanan Bloomer, Savannah R. Parker, Wesley Clawson, M. Caron et autres
Abstract The tumor microenvironment in triple-negative breast cancer (TNBC) is characterized by increased sensory nerve density, which contributes to cancer progression by promoting migration and metastasis. However, the origin of tumor-innervating nerves and the mechanisms driving sensory innervation into tumors remain poorly …
us, vn
(code pays fourni par la source)
2025
article
OpenAlex
Gat Rauner, Piyush B. Gupta, Charlotte Kuperwasser
us
(code pays fourni par la source)
2025
article
OpenAlex
Meadow E. Parrish, Charlotte Kuperwasser
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Colin Trepicchio, Gat Rauner, Nicole Traugh, Ruohong Wang et autres
Understanding epithelial stem cell differentiation and morphogenesis during breast tissue development is essential, as disruption in these processes underlie breast cancer formation. We used a next-generation single-cell-derived organoid model to investigate how individual stem cells give rise to complex tissue. We show …
us
(code pays fourni par la source)
2025
preprint
OpenAlex
Nicole Traugh, Colin Trepicchio, Gat Rauner, Meadow E. Parrish et autres
Abstract Mesenchymal-epithelial interactions are well-established for organogenesis, but the role of immune cells in these processes remains less explored. Organoids offer powerful models for studying tissue development, especially where in vivo models are limited. In this study, we established an immune-epithelial co-culture …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Gat Rauner, Nicole Traugh, Colin J. Trepicchio, Meadow E. Parrish et autres
Organoids have emerged as a powerful tool for modeling tissue growth and diseases. In this study, we introduce a groundbreaking organotypic culture technique that replicates the morphology, scale, and heterogeneity of human breast tissue, and includes a mesenchymal-like stromal component. A standout …
Accès ouvert
2024
supplementary-materials
OpenAlex
Glenn J. Hanna, Scott A. Roof, James Jabalee, Eleni M. Rettig et autres
Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance
Accès ouvert
2024
supplementary-materials
OpenAlex
Glenn J. Hanna, Scott A. Roof, James Jabalee, Eleni M. Rettig et autres
Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance