Iman Sahnoune

ABCL-615: EPCORE NHL-6: Phase 2 Study of Subcutaneous Epcoritamab as Outpatient Treatment for 2L+ Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Christina Y. Lee, David Andorsky, Ralph Boccia, Adelba Torres Lopez et autres

us, pr (code pays fourni par la source)

POSTER: ABCL-615: EPCORE NHL-6: Phase 2 Study of Subcutaneous Epcoritamab as Outpatient Treatment for 2L+ Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Christina Y. Lee, David Andorsky, Ralph Boccia, Adelba Torres Lopez et autres

us, pr (code pays fourni par la source)

EPCORE NHL-6: Phase 2 study of subcutaneous (SC) epcoritamab as outpatient treatment for 2L+ relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL).

Christina Y. Lee, David Andorsky, Ralph Vincent Boccia, Adelba Liz Torres et autres

e19003 Background: Epcoritamab, a CD3×CD20 bispecific antibody approved for R/R DLBCL, is administered SC with inpatient monitoring for 24 h after the first full dose (FFD). Previous report from NHL-6 (NCT05451810) demonstrated feasibility of outpatient dosing and monitoring of epcoritamab in 2L+ …

us, pr (code pays fourni par la source)

The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers

Recep Bayraktar, Yitao Tang, Mihnea Paul Dragomir, Cristina S. Ivan et autres

The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance in cancers remain poorly characterized. Here, we perform a systematic analysis of whole-genome and in-house targeted UCE sequencing datasets from more than 3000 patients …

us, de, it, au, si, fr (code pays fourni par la source)

A Novel Small Molecule Targeting Oncogenic miR-10b in Gastric Cancer

Paola C Rausseo, Iman Sahnoune, George A Calin

Abstract A05: Molecular, immunologic, metabolic, and radiomic associations of oxidative phosphorylation (OXPHOS) in melanoma brain metastases (MBMs)

Grant M. Fischer, Aikaterini Kotrotsou, Sara Ahmed, Pilar O’Neal et autres

Abstract Background: OXPHOS mediates resistance to BRAF and MEK inhibitors in melanoma. Recently, we showed that MBMs have higher expression of OXPHOS genes than patient-matched extracranial metastases (ECMs). The induction of, and dependence upon, OXPHOS in MBMs was confirmed in mouse xenograft …

us (code pays fourni par la source)

Inflammation systémique dans la BPCO : influence-t-elle la fréquence des exacerbations ?

Houda Gharsalli, Mounir Hamdi, Mohamed Larbi Masmoudi, Iman Sahnoune et autres

Tunisie (code pays fourni par la source)

Non-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and Cancer

Baoqing Chen, Junyan Li, Dongmei Chi, Iman Sahnoune et autres

The intricate molecular network shared between diabetes mellitus (DM) and cancer has been broadly understood. DM has been associated with several hormone-dependent malignancies, including breast, pancreatic, and colorectal cancer (CRC). Insulin resistance, hyperglycemia, and inflammation are the main pathophysiological mechanisms linking DM …

us, cn, se (code pays fourni par la source)

Long Non-coding RNAs in Myeloid Malignancies

Alina‐Andreea Zimța, Ciprian Tomuleasa, Iman Sahnoune, George Adrian Calin et autres

Acute myeloid leukemia (AML) represents 80% of adult leukemias and 15-20% of childhood leukemias. AML are characterized by the presence of 20% blasts or more in the bone marrow, or defining cytogenetic abnormalities. Laboratory diagnoses of myelodysplastic syndromes (MDS) depend on morphological …

ro, us (code pays fourni par la source)

Sustainability via Active Garden Education: Translating Policy to Practice in Early Care and Education

Rebecca E. Lee, Erica G. Soltero, Tracey A. Ledoux, Iman Sahnoune et autres

BACKGROUND: We describe the development of sustainability via active garden education (SAGE), an early care and education (ECE) garden-based curriculum developed from a 5-year community partnership to link national health policy guidelines with ECE accreditation standards. METHODS: National health guidelines and ECE …

us (code pays fourni par la source)

Exercise ameliorates neurocognitive impairments in a translational model of pediatric radiotherapy

Iman Sahnoune, Taeko Inoue, Shelli R. Kesler, Shaefali P. Rodgers et autres

Background: While cranial radiation therapy (CRT) is an effective treatment, healthy areas surrounding irradiation sites are negatively affected. Frontal lobe functions involving attention, processing speed, and inhibition control are impaired. These deficits appear months to years after CRT and impair quality of …

us (code pays fourni par la source)

Neurosurgical Applications of High-Intensity Focused Ultrasound with Magnetic Resonance Thermometry

Rivka R. Colen, Iman Sahnoune, Jeffrey S. Weinberg

us (code pays fourni par la source)