Cristina Simonet

Digital motor and cognitive variability as early markers of the prodromal Parkinson’s disease spectrum

Harneek Chohan, Sheena Waters, Laura Pérez-Carbonell, Guy Leschziner et autres

ABSTRACT Background Individuals with isolated REM sleep behaviour disorder (iRBD) show motor and cognitive dysfunction prior to clinical α-synucleinopathy. Performance instability may represent an earlier marker of neurodegeneration but remains underexplored using digital tests. Objectives To assess baseline and longitudinal differences in …

gb, es (code pays fourni par la source)

Perceived consequences and catastrophising help explain health-related quality of life in Parkinson's disease. A cross-sectional study

Viktoria Azoidou, Essa Bhadra, Ellen Camboe, Kamalesh C. Dey et autres

Introduction Motor complications are major determinants of disability in Parkinson's disease (PD), yet clinician-rated motor complication severity does not fully explain variability in health-related quality of life (HRQoL). This study examined the contribution of illness perceptions and cognitive-behavioural responses to HRQoL alongside …

gb (code pays fourni par la source)

Sternum-worn vibrotactile device in Parkinson’s disease: a randomised, double-blind, placebo-controlled pilot trial

Viktoria Azoidou, Essa Bhadra, Ellen Camboe, Kamalesh C. Dey et autres

Effective, non-invasive treatments for motor and non-motor symptoms in Parkinson's disease (PD) remain limited, and wearable vibrotactile stimulation may help by enhancing sensorimotor integration. This multi-centre, double-blind, pilot randomised controlled trial evaluated the usability, safety and tolerability of the CUE1+ sternum-worn vibrotactile …

gb (code pays fourni par la source)

Pathology and Genetics in a Global Cohort of Parkinsonian Disorders

Lesley Y. Wu, Tessa du Toit, Tatiana Georgiades, Eleanor J. Stafford et autres

Importance: Accurate diagnosis of neurodegenerative movement disorders is challenging because of a lack of in vivo biomarkers, overlapping clinical features, and a delay in the emergence of pathognomonic features. Objective: To evaluate clinicopathological correlation, diagnostic accuracy, genetic association with pathology, and ancestry-related …

gb, us, de, au, it (code pays fourni par la source)

Wearable Evidence Linking Dyskinesia Burden to Sleep Quality in Parkinson’s Disease

Viktoria Azoidou, Essa Bhadra, Ellen Camboe, Kamalesh C. Dey et autres

Abstract Background Sleep disturbances affect up to 60-80% of people with Parkinson’s disease (PD) and are associated with worse clinical outcomes and reduced quality of life. Dyskinesia is a common motor complication of dopaminergic therapy, but its relationship with sleep quality remains …

gb (code pays fourni par la source)

PREDICT ‐ PD : A Two‐Stage Approach to Early Identification of Parkinson's Disease

Sasivimol Virameteekul, Sheena Waters, Brook Huxford, Ashvin Kuri et autres

gb, th, no (code pays fourni par la source)

Synuclein and dopamine transporter biomarkers among phenoconverters to parkinsonian disorders

Cristina Simonet, K. Yi, Lana Chahine, Daniel Weintraub et autres

This repository contains analysis codes supporting the manuscript “Synuclein and dopamine transporter biomarkers among phenoconverters to parkinsonian disorders.” Code files are organized by analysis outputs (tables and figures) and are intended to facilitate transparency and reproducibility of the reported findings. Analytic datasets …

us (code pays fourni par la source)

Synuclein and dopamine transporter biomarkers among phenoconverters to parkinsonian disorders

Cristina Simonet, K. Yi, Lana Chahine, Daniel Weintraub et autres

This repository contains analysis codes supporting the manuscript “Synuclein and dopamine transporter biomarkers among phenoconverters to parkinsonian disorders.” Code files are organized by analysis outputs (tables and figures) and are intended to facilitate transparency and reproducibility of the reported findings. Analytic datasets …

us (code pays fourni par la source)

Perceived Consequences and Catastrophising Help Explain Health-Related Quality of Life in Parkinson’s Disease. A Cross-Sectional Study

Viktoria Azoidou, Essa Bhadra, Ellen Camboe, Kamalesh C. Dey et autres

ABSTRACT Introduction Motor complications are major determinants of disability in Parkinson’s disease (PD), yet clinician-rated motor complication severity does not fully explain variability in health-related quality of life (HRQoL). Research question To examine the contribution of illness perceptions and cognitive-behavioural responses to …

gb (code pays fourni par la source)

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair et autres

OBJECTIVE: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker-defined synucleinopathy. METHODS: Parkinson's Progression …

us, il, de, gb (code pays fourni par la source)

Synuclein and dopamine transporter biomarkers among phenoconverters to parkinsonian disorders

Cristina Simonet, K. Yi, Lana M. Chahine, Daniel Weintraub et autres

Abstract Background Phenoconversion to Parkinson’s disease (PD) or dementia with Lewy bodies (DLB) currently relies on established clinical diagnostic criteria. Availability of in vivo biomarkers—CSF α-synuclein seed amplification assay (CSFaSynSAA) and dopamine transporter (DAT) imaging—offer the opportunity to investigate congruency between clinical …

gb, us, de, il (code pays fourni par la source)

Handwriting patterns in isolated rapid eye movement sleep behaviour disorder

Roberta Torricelli, Jack ES Kenny, Emma Bache, L. Pérez-Carbonell et autres

BackgroundHandwriting changes are recognised as an early manifestation of Parkinson's disease. Whilst isolated rapid eye movement sleep behaviour disorder (iRBD) is strongly associated with future Parkinson's diagnosis, changes in handwriting remain under-explored.ObjectiveTo assess the handwriting of people with iRBD and develop a …

gb, au (code pays fourni par la source)