Harry A. Fagan

The pharmacological rationale for amiloride nasal spray: potentially a portable and rapid acting treatment for panic disorder: commentary, Fagan

Harry A. Fagan

gb (code pays fourni par la source)

Effects of opioid antagonism on functional MRI correlates of explicit and implicit threat processing in healthy volunteers

Nathan T. M. Huneke, Henk van Steenbergen, Harry A. Fagan, Laura Molteni et autres

BACKGROUND: We need to identify novel, tractable therapeutic targets for anxiety disorders. Converging evidence suggests the endogenous opioid system plays a role in modulating affective processing, but its contribution to regulation of threat processing in humans remains unclear. AIMS: We investigated the …

gb, nl (code pays fourni par la source)

Integrative Systematic Review on Pharmacological, Psychotherapeutic, and Neurostimulatory Treatment Options in Treatment-Resistant Anxiety Disorders

Miriam A. Schiele, Harry A. Fagan, David S. Baldwin, Katharina Domschke

INTRODUCTION: Treatment resistance in anxiety disorders (TR-ADs) constitutes a major clinical challenge conferring a considerable burden regarding quality of life and societal health costs. METHODS: This systematic review provides an overview of pharmacological, psychotherapeutic, and neurostimulatory treatment options in adults with treatment-resistant …

de, gb, Afrique du Sud (code pays fourni par la source)

The elusive neural signature of emotion regulation capabilities: evidence from a large-scale consortium

Maurizio Sicorello, Jenny Zaehringer, Lena M. Paschke, Rosa Steimke et autres

Abstract Cognitive reappraisal is a fundamental emotion regulation strategy for mental and physical well-being, but how its neural mechanisms relate to individual differences remains poorly understood. In a consortium effort analyzing 40 fMRI datasets ( N =2,175), we examined the relationship between …

de, us, fr, kr, gb, nl, es, au, si, pl, ch, at (code pays fourni par la source)

Development of an assay for measuring the functional effects of novel compounds at extrasynaptic GABA-A receptors

Harry A. Fagan, John R. Atack, Karen T Elvers

gb (code pays fourni par la source)

Seeing the bigger picture: endogenous opioids mediate attentional broadening after reward receipt

Henk van Steenbergen, Philip A. Gable, Harry A. Fagan, Laura Molteni et autres

BACKGROUND: Contemporary society faces significant challenges that can lead to stress-induced tunnel vision. Positive affect can counteract these effects by expanding humans' attentional scope, potentially promoting resilience and creativity. This preregistered triple-blind study investigated the role of endogenous opioids in mediating attentional …

nl, us, gb (code pays fourni par la source)

Seeing the bigger picture: Endorphins mediate attentional broadening after reward receipt (PREPRINT)

Henk van Steenbergen, Philip A. Gable, Harry A. Fagan, Laura Molteni et autres

Contemporary society faces significant challenges, that can lead to stress-induced tunnel vision. Research has shown that positive affect can counteract these effects by expanding humans' attentional scope, potentially promoting resilience and innovative thinking. However, the neurochemical mechanism underlying these effects remains unknown. …

Anxiety disorders, post-traumatic stress disorder and obsessive–compulsive disorder

Harry A. Fagan, Bethan Impey, David S. Baldwin

gb (code pays fourni par la source)

Effects of mindfulness-based interventions on symptoms and interoception in trauma-related disorders and exposure to traumatic events: Systematic review and meta-analysis

Laura Molteni, Corentin J. Gosling, Harry A. Fagan, Joshua Hyde et autres

Interoception is defined as the sense of the internal state of the body. Dysfunctions in interoception are found in several mental disorders, including trauma-related conditions. Mindfulness-Based Interventions (MBIs) have been shown to influence interoceptive processes. Randomised controlled trials (RCTs) have investigated whether …

gb, it, fr, us, Afrique du Sud (code pays fourni par la source)

Placebo Effects Are Small on Average in the 7.5% CO2 Inhalational Model of Generalized Anxiety

Nathan T. M. Huneke, Cosmina Cross, Harry A. Fagan, Laura Molteni et autres

BACKGROUND: Anxiety disorders are highly prevalent and socio-economically costly. Novel pharmacological treatments for these disorders are needed because many patients do not respond to current agents or experience unwanted side effects. However, a barrier to treatment development is the variable and large …

gb, Afrique du Sud (code pays fourni par la source)

The definition of treatment resistance in anxiety disorders: a Delphi method‐based consensus guideline

Katharina Domschke, Patrik D. Seuling, Miriam A. Schiele, Borwin Bandelow et autres

Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials of innovative therapeutic interventions. However, an explicit definition of treatment-resistant anxiety disorders (TR-AD) informing such trials is currently lacking. We …

de, nl, it, lt, ca, gb, jp, au, rs, gr, br, us, Afrique du Sud, in (code pays fourni par la source)

The role of the orexin system in the neurobiology of anxiety disorders: Potential for a novel treatment target

Harry A. Fagan, Nathan T. M. Huneke, Katharina Domschke, David S. Baldwin

Anxiety disorders constitute the most common group of psychiatric disorders with a lifetime prevalence of 14.5-33.7%. Despite efficacious pharmacological and psychological treatments, first line treatment is often not effective, and development of new therapies is needed. One area of interest is the …

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