Neal Matsumori Rao

Is there diurnal variation in Magnesium neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?

Fatima Pariona-Vargas, Katherine T Mun, Eng H. Lo, Sidney J. Starkman et autres

BACKGROUND: Preclinical studies have found marked diurnal/circadian variation in the effect of neuroprotective agents in acute ischemic stroke. However, the presence of diurnal variation in treatment outcomes after neuroprotective therapy has not been analyzed in human clinical trials and variation after thrombolytic …

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A Deep Learning Approach to Predict Recanalization First-Pass Effect following Mechanical Thrombectomy in Patients with Acute Ischemic Stroke

Haoyue Zhang, Jennifer Polson, Zichen Wang, Kambiz Nael et autres

BACKGROUND AND PURPOSE: Following endovascular thrombectomy in patients with large-vessel occlusion stroke, successful recanalization from 1 attempt, known as the first-pass effect, has correlated favorably with long-term outcomes. Pretreatment imaging may contain information that can be used to predict the first-pass effect. …

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Water content for clot composition prediction in acute ischemic stroke

Kenichi Sakuta, Taichiro Imahori, Amir M. Molaie, Mahsa Ghovvati et autres

BACKGROUND: Mechanical thrombectomy (MT) has become the gold standard care for treating acute ischemic stroke (AIS) due to large vessel occlusion. Emerging evidence suggests that understanding the composition of clots prior to intervention could be useful for the selection of neuroendovascular techniques, …

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Abstract WP9: Ischemic Stroke Progression After Witnessed Onset in Daytime vs Night-Time

Fatima Pariona-Vargas, Katherine T Mun, Sidney J. Starkman, Nerses Sanossian et autres

Introduction: Early neurologic deterioration (END) and poor functional outcomes are more frequent with night than daytime onset of ischemic stroke. This variation may be related to: 1) circadian variation endogenous bodily rhythms and/or 2) extrinsic environmental time cues. Methods: To assess the …

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Abstract 275: Hypothesizing After Results are Known (HARKing) in Neurovascular Research Induced by Meeting Abstract Preparation Guidelines

Venya Vaddi, Jesse W. Hou, Neal Matsumori Rao, Jeffrey L. Saver

Introduction A “reproducibility crisis” has afflicted the recent medical literature, affecting 75‐89% of major reported findings. An important cause of the inability to replicate results is hypothesizing after the results are known (HARKing): presenting a post hoc hypothesis according with findings as …

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Circadian variation in stroke onset: Differences between ischemic and hemorrhagic stroke and weekdays versus weekends

Fatima Pariona-Vargas, Katherine T Mun, Eng H. Lo, Sidney J. Starkman et autres

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Abstract TP43: Circadian Variation In Stroke Onset On Weekdays Compared With Weekends/Holidays

Fatima Pariona-Vargas, Katherine T Mun, Eng H. Lo, Sidney J. Starkman et autres

Background: Ischemic and hemorrhagic stroke onset exhibit is known to exhibit diurnal variation throughout the 24-hour cycle. But whether this variation differs on weekdays compared with weekends/holidays has not been well delineated. Methods: We evaluated consecutive patients with acute cerebral ischemia [(ACI), …

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Abstract TMP90: The Harm Sign As A Trial Biomarker Of Reperfusion Injury: Frequency, Determinants, And Outcomes In EVT Patients With Successful Reperfusion

Salman Farooq, David S Liebeskind, Reza Jahan, Bryan Y. Yoo et autres

Introduction: With successful reperfusion (SR, mTICI 2b-3) now being achieved in the great preponderance of patients undergoing endovascular thrombectomy (EVT), prevention of blood-brain barrier disruption and reperfusion injury is an emerging therapeutic target. For trials of agents to reduce BBB injury, the …

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Reduced Leukoaraiosis, Noncardiac Embolic Stroke Etiology, and Shorter Thrombus Length Indicate Good Leptomeningeal Collateral Flow in Embolic Large-Vessel Occlusion

Tetsuya Hashimoto, Takenobu Kunieda, Tristan Honda, Fabien Scalzo et autres

BACKGROUND AND PURPOSE: Acute leptomeningeal collateral flow is vital for maintaining perfusion to penumbral tissue in acute ischemic stroke caused by large-vessel occlusion. In this study, we aimed to investigate the clinically available indicators of leptomeningeal collateral variability in embolic large-vessel occlusion. …

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Abstract 1122‐000182: Histological Composition of Large Vessel Occlusion Stroke‐Causing Thrombi to Identify Etiologies: Systematic Review and Meta‐Analysis

Paul Yeung‐Lai‐Wah, Kunakorn C. Atchaneeyasakul, Kyle Sheu, Neal Matsumori Rao et autres

Introduction : More than a third of large vessel occlusion ischemic strokes do not have clear etiology. Mechanical thrombectomy provides a method to retrieve stroke‐causing thrombi and potentially identifying the etiology. A systematic meta‐analysis is performed to determine if there is a …

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Heterogeneity between proximal and distal aspects of occlusive thrombi on pretreatment imaging in acute ischemic stroke

Tetsuya Hashimoto, Takenobu Kunieda, Tristan Honda, Fabien Scalzo et autres

Background The potential heterogeneity in occlusive thrombi caused by in situ propagation by secondary thrombosis after embolic occlusion could obscure the characteristics of original thrombi, preventing the clarification of a specific thrombus signature for the etiology of ischemic stroke. We aimed to …

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Frequency, Determinants, and Outcomes of Emboli to Distal and New Territories Related to Mechanical Thrombectomy for Acute Ischemic Stroke

Gregory J. Wong, Bryan Y. Yoo, David S. Liebeskind, Humain Baharvahdat et autres

Background and Purpose: Clot fragmentation and distal embolization during endovascular thrombectomy for acute ischemic stroke may produce emboli downstream of the target occlusion or in previously uninvolved territories. Susceptibility-weighted magnetic resonance imaging can identify both emboli to distal territories (EDT) and new …

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