Zhidong Tu

A Multi-Omics Study of Cognitive Resilience to Alzheimer’s Disease

Erming Wang, Boer Xie, Minghui Wang, Yingxue Fu et autres

Abstract Alzheimer’s disease (AD) is the most severe form of dementia. While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience. Substantial …

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Molecular Networks and Key Regulators Underlying Resilience of the Human Brain to Aging and Dementia

Lei Guo, Nicholas Grimaldi, Minghui Wang, Lap Ho et autres

Alzheimer’s disease (AD) is an aging-related neurodegenerative disease characterized by an initial memory impairment that progresses to a widespread cerebrocortical failure, culminating in death. Understanding the molecular mechanisms that protect brain function during aging may help reveal novel targets for the development …

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Correction to: Follow-up timing of 24 pulsars discovered in commensal radio astronomy FAST survey

Q. D. Wu, J. P. Yuan, Na Wang, Di Li et autres

In the published paper (Q. D. Wu et al. 2023), linear polarization position angles (PAs) and the signs of Faraday rotation measurements were incorrect due to errors in data processing during the polarization calibration process (specifically, the sign flip of Stokes Q …

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HALMF: High-performance Approximate Logarithmic Multiplier based on FPGA

Xin He, Zhidong Tu, Yi Guo

To enhance the performance of computationally intensive intelligent applications, approximate multipliers leveraging error tolerance have been widely explored for improving the power and performance efficiency of computing units. FPGAs, with their reconfigurability and short development cycles, offer a flexible platform for deploying …

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Human brain aging heterogeneity observed from multi-region omics data reveals a subtype closely related to Alzheimer’s disease

Shouneng Peng, Erming Wang, Minghui Wang, Xusheng Wang et autres

Abstract INTRODUCTION: The interconnection between brain aging and Alzheimer’s disease (AD) remain to be elucidated. METHODS: We investigated multi-omics (transcriptomics and proteomics) data from multiple brain regions (i.e., the hippocampus (HIPP), prefrontal cortex (PFC), and cerebellum (CRBL)) in cognitively normal individuals. RESULTS: …

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Cosmological constraints from type-I radio-loud quasars

Long Huang, Zhidong Tu, Ning Chang, Fangfang Song et autres

We obtain a sample of 1192 type-I quasars with the UV-optical, radio, and x-ray waveband coverage, which combined with the data from Huang and Chang [Mon. Not. R. Astron. Soc. 515, 1358 (2022)] and other matching objects of SDSS-DR16 with FIRST, XMM-Newton, …

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Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence

Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C. An et autres

Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcriptomes of 10 experimental senescence cell models with a 224 …

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Cosmological constraints from Type I radio-loud quasars

L. Q. Huang, Zhidong Tu, Ning Chang, Fangfang Song

We obtain a new sample of 1192 Type I quasars with the UV-optical, radio and X-ray wavebands coverage by combining \citet{Huang2022} and other matching data of SDSS-DR16 with FIRST, XMM-Newton, and Chandra Source Catalog, and a sample of 407 flat-spectrum radio-loud quasars …

Identification of brain aging subtypes in multiple brain regions from cognitively normal individuals

Shouneng Peng, Jean‐Vianney Haure‐Mirande, Minghui Wang, Derek M. Huffman et autres

Abstract Background Although late‐onset Alzheimer’s disease (LOAD) occurs in older individuals (age 65 or older), multiple lines of evidence suggests that the dysregulation of brain functions initiates decades earlier. Through examining multiple large‐scale human brain transcriptomic data, we demonstrated that cognitively normal …

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Molecular differences in brain regional vulnerability to aging between males and females

Xianxiao Zhou, Jiqing Cao, Li Zhu, Kurt Farrell et autres

Background Aging-related cognitive decline is associated with brain structural changes and synaptic loss. However, the molecular mechanisms of cognitive decline during normal aging remain elusive. Results Using the GTEx transcriptomic data from 13 brain regions, we identified aging-associated molecular alterations and cell-type …

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Follow-up timing of 24 pulsars discovered in commensal radio astronomy FAST survey

Q. D. Wu, J. P. Yuan, Na Wang, Di Li et autres

ABSTRACT The follow-up timing observations were carried out for 24 pulsars discovered with the Five-hundred-meter Aperture Spherical radio Telescope (FAST) in Commensal Radio Astronomy FAST Survey. We report their phase-connected timing ephemeris, polarization pulse profiles, and Faraday rotation measurements. With their spin …

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Multiscale network analysis identifies potential receptors for SARS‐CoV ‐2 and reveals their tissue‐specific and age‐dependent expression

Christian V. Forst, L. Zeng, Qian Wang, Xianxiao Zhou et autres

The coronavirus disease 2019 (COVID-19) pandemic has affected tens of millions of individuals and caused hundreds of thousands of deaths worldwide. Here, we present a comprehensive, multiscale network analysis of the transcriptional response to the virus. In particular, we focused on key …

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