Anil Rane

Assisted Versus Unassisted Domiciliary Alcohol Detoxification: A Randomized Controlled Trial

S Suresh, Anil Rane

Background: Detoxification stands as a crucial phase in the treatment of alcohol use disorders (AUD), yet only limited data is available on the outcomes of home-based detoxification. Assisted domiciliary detoxification involves monitoring an individual’s withdrawal progress, while offering psychosocial support and detoxification …

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An Exploratory Evaluation of Implementing a Rapid-response Online Mental Health Service During the COVID-19 Pandemic: A Mixed Methods Study from India

Ravindra Narayan Agrawal, Kimberley Monteiro, Bijayalaxmi Biswal, Brinda Singh Raikwar et autres

OBJECTIVES: Strict social distancing and lockdown measures imposed to curb transmission during the early phase of the outbreak of the COVID-19 pandemic posed challenges to people's psychological wellbeing, limited access to social support, and disrupted routine mental health service delivery. In response, …

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Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling

Yiyang Liu, Sébastien Monfette, Russell F. Algera, Andrew Davidson et autres

Abstract The development of a robust process for a Pd-catalyzed Buchwald–Hartwig C–N coupling reaction to manufacture PF-06842874, a clinical candidate for the treatment of pulmonary arterial hypertension, on kilogram scale is reported. The variability in reaction kinetics initially encountered was resolved via …

DIAGNOSTIC TRENDS IN PATIENTS WITH ORGANIC BRAIN SYNDROME PRESENTING TO TERTIARY PSYCHIATRIC HOSPITAL IN GOA

Vanshika Malik, Sneha Pokle, Anil Rane

Organic Brain Syndromes also known as Organic Mental Disorders, are afictions of the brain that can lead to severe behavioural or psychiatric problems. These disorders may be temporary or permanent in nature, and may be attributed to hereditary or caused by disease, …

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Acceptability and feasibility of assisted telepsychiatry in routine healthcare settings in India: a qualitative study

Abhijit Nadkarni, Ankur Garg, Ravindra Narayan Agrawal, Seema Sambari et autres

Technology-enabled interventions are often recommended to overcome geographical barriers to access and inequitable distribution of mental healthcare workers. The aim of this study was to examine the acceptability and feasibility of an assisted telepsychiatry model implemented in primary care settings in India. …

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Integrating assisted tele-psychiatry into primary healthcare in Goa, India: a feasibility study

Ankur Garg, Ravindra Narayan Agrawal, Richard D. B. Velleman, Anil Rane et autres

Abstract Background Tele-psychiatry is an increasingly acceptable and feasible platform to deliver mental health care with the potential to increase access to care in low-resource settings. We aim to examine the acceptability and preliminary impact of the delivery of assisted tele-psychiatry services …

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Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor

Rajesh Kumar, Michael J. Karmilowicz, Dylan Burke, Michael P. Burns et autres

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Role of Waste Decomposer in Biogas and Energy Generation

Anil Rane

Biocatalytic Reductive Amination- Discovery to Commercial Manufacturing applied to Abrocitinib JAK1 inhibitor

Rajesh Kumar, Michael J. Karmilowicz, Dylan Burke, Michael J. Burns et autres

Abstract The authors have requested that this preprint be removed from Research Square.

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Prevalence and Correlates of Metabolic Syndrome in Severe Mental Illness

Akshada Sabnis, Anil Rane, Abhijit Nadkarni

Background: People with severe mental illness (SMI) die prematurely. They also have disproportionately high burden of diabetes, dyslipidemia, and obesity, which is further compounded by unhealthy lifestyle such as sedentary behavior and substance use. Consequently, there is a high prevalence of metabolic …

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Domiciliary alcohol detoxification outcomes: a study from Goa, India

Saumitra Nemlekar, Pooja Gaonkar, Anil Rane

Alcohol use disorder (AUD) is a significant public health problem across all regions of the world. Overall evidence regarding outcomes is available from western regions. Detoxification is one of the first steps in treating AUDs. The following case note review looks at …

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Development of a Scalable Synthesis for an Inhaled pan-JAK Inhibitor

Alexander V. Gontcharov, Javier Magano, Lacey Samp, Tim L. Houck et autres

A scalable synthesis of a pan-JAK inhibitor is described. The original synthesis by the Medicinal Chemistry group has been modified to develop a new protecting group strategy, a 3-step telescoped synthesis to generate an imidazole ring from a nitrile, and a telescoped …

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