Lukasz S. Borowski

Loss of epitranscriptomic mitochondrial RNA surveillance drives epithelial type I interferon and inflammation in autoimmunity

Alejandro Arco-Hierves, Konstantina Pamboukas, Linda Bilonda Mutala, Lukasz S. Borowski et autres

Chronic interferon (IFN) activation is a hallmark of autoimmune diseases such as systemic lupus erythematosus and Sjögren’s disease (SjD), where epithelial cells are key contributors. Although viral and retroelement triggers have been proposed as triggers, direct evidence in patient tissues is limited, …

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TTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity

Rafał Tomecki, Małgorzata Drabko, Małgorzata Siek, Maria Matykiewicz et autres

The functions of many human proteins remain unknown, highlighting major gaps in our understanding of cellular biology. TTC33 is an evolutionarily conserved tetratricopeptide repeat (TPR) protein expressed across human tissues, whose molecular role is not defined. Here we identify the TTC33 partners …

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Genome-wide in vivo and ex vivo mapping of R-loops using engineered N-terminal hybrid-binding domain of RNase H3 (enDR3)

Marta Jedynak-Slyvka, Zuzanna Kaczmarska, Damian Graczyk, Aneta Jurkiewicz et autres

R-loops are nucleic acid structures composed of an RNA/DNA hybrid and a displaced single-stranded DNA that form during transcription. Their defective processing has been implicated in genome instability, which is associated with severe human diseases. Despite their biological significance, the mechanisms regulating …

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Investigation of spectroelectrochemical processes of JC-1 cyanine dye combined with gold nanoparticles, an important indicator of mitochondrial membrane potential: theoretical and EC-SERS studies

Kacper Jędrzejewski, Oliwier Misztal, Janusz Cukras, Krystian Pupel et autres

pl (code pays fourni par la source)

Coupling translation termination to RNA surveillance: roles of release factors in quality control and RNA degradation pathways in mammalian mitochondria

Joanna Rorbach, Annika Marie Krüger, Daria Alexandrovna Kovalchuk, Lukasz S. Borowski et autres

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POLR1D, a shared subunit of RNA polymerase I and III, modulates mTORC1 activity

Neuton Gorjão, Lukasz S. Borowski, Roman J. Szczęsny, Damian Graczyk

pl (code pays fourni par la source)

Valuation and Volatility of Virtual Properties in Metaverse: Exploring New Market Opportunities and Speculative Dynamics Based on Decentraland

Karol Narowski, Lukasz S. Borowski, Michał Apollo, Kamil Maciuk

Existing reality has been repeatedly subjected to multifaceted and multidimensional analyses. However, alongside it, a virtual reality exists, populated with virtual art, objects in games, cyber-pets, and virtual properties, collectively worth billions of real dollars. This virtual reality is associated with the …

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The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

Magda Wąchalska, Celeste Riepe, Magdalena J. Ślusarz, Małgorzata Graul et autres

The transporter associated with antigen processing (TAP) is a key player in the major histocompatibility class I-restricted antigen presentation and an attractive target for immune evasion by viruses. Bovine herpesvirus 1 impairs TAP-dependent antigenic peptide transport through a two-pronged mechanism in which …

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The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

Magda Wąchalska, Celeste Riepe, Magdalena J. Ślusarz, Małgorzata Graul et autres

ABSTRACT The transporter associated with antigen processing (TAP) is a key player in the MHC class I-restricted antigen presentation and an attractive target for immune evasion by viruses. Bovine herpesvirus 1 (BoHV-1) impairs TAP-dependent antigenic peptide transport through a two-pronged mechanism in …

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High-Throughput Image-Based Quantification of Mitochondrial DNA Synthesis and Distribution

Lukasz S. Borowski, Karolina Kasztelan, Jolanta Czerwińska, Roman J. Szczęsny

The vast majority of cellular processes require a continuous supply of energy, the most common carrier of which is the ATP molecule. Eukaryotic cells produce most of their ATP in the mitochondria by oxidative phosphorylation. Mitochondria are unique organelles because they have …

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Développement d’un modèle cellulaire corticosurrénalien de modulation de l’équilibre calcique pour décrypter les conséquences moléculaires des mutations responsables d’hyperaldostéronisme primaire

Bakhta Fedlaoui, Teresa Cosentino, Isabelle Giscos-Douriez, Lukasz S. Borowski et autres

fr, us (code pays fourni par la source)

Mitochondrial RNA , a new trigger of the innate immune system

Joanna Grochowska, Jolanta Czerwińska, Lukasz S. Borowski, Roman J. Szczęsny

Mitochondria play a pivotal role in numerous cellular processes. One of them is regulation of the innate immune pathway. In this instance, mitochondria function in two different aspects of regulatory mechanisms. First, mitochondria are part of the antiviral signaling cascade that is …

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