Fangfang Fan

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Jinghan Yang, Qiang Dai, Jiaxing Ke, Feng Peng et autres

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association between plasma 25(OH)D and serum Hcy, along with …

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Intensified background therapy enhances mortality benefit of SGLT2 inhibitors in heart failure: a retrospective cohort study

Qixian Zhang, Fangfang Fan, Fan Yang, Zuoyi Zhou et autres

SGLT2 inhibitors (SGLT2is) improve outcomes in patients with heart failure (HF), but their effects may depend on background medical therapy. The Heart Failure Collaboratory score, which incorporates medication type and dose, may modify the benefit of SGLT2is. To evaluate the association between …

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Integrated Transcriptomic and Phenotypic Analyses Reveal Tissue-Specific Nitrogen Responses and Candidate Genes for Low-Nitrogen Tolerance in Sorghum

Fangfang Fan, Xiaoqiang Cheng, Yao Wang, Jirong Wu et autres

Sorghum (Sorghum bicolor (L.) Moench) is an important crop with remarkable tolerance to adverse environments, including nitrogen deficiency. To investigate the mechanisms underlying sorghum tolerance to low-nitrogen (LN) stress, we integrated phenotypic evaluation, transcriptome profiling, weighted gene co-expression network analysis (WGCNA), and …

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Identifying Epithelial-Cell Progression Signatures (ECPSs) from Multi-Resolution Multi-Omics Data for Translational Clinical Applications in Lung Adenocarcinoma

Xueyao Chen, Tongxin Lv, Yang Wu, Fangfang Fan et autres

Dynamic transcriptomic remodeling of epithelial cells represents a critical hallmark of lung adenocarcinoma (LUAD) progression, yet epithelial-cell progression signatures (ECPSs) linked to this process remain incompletely characterized, impeding our understanding of malignant LUAD transformation. Here, we performed a multi-resolution multi-omics study and …

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Lignin Content Alone Does Not Determine Lodging Resistance in Forage Sorghum: Roles of Stem Anatomy and Divergent Accessions

Hao Niu, Yue Wang, Xiaoqiang Cheng, R X Liu et autres

Forage sorghum (Sorghum bicolor (L.) Moench) has excellent stress resistance and feeding quality. Lodging is one of the most critical factors influencing its yield and overall quality. However, there remains no definitive conclusion regarding the key indicators affecting the lodging of forage …

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Comparison of Vascular Aging Models on the Basis of Different Vascular Indicators for Cardiovascular Events Prediction: A Chinese Community‐Based Cohort Study

Haotai Xie, Fangfang Fan, J Jia, Jianping Li et autres

BACKGROUND: Vascular aging (VA) is a promising concept for cardiovascular risk assessment, but the optimal vascular indicator for vascular age calculation remains uncertain. This study aimed to compare VA indices on the basis of different vascular indicators for predicting cardiovascular events. METHODS: …

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Targeting cytokine-like protein FAM3D alleviates atherosclerosis

Shirong Zhu, Minzhe Zhu, Fangfang Fan, Cai Zm et autres

Despite effective cholesterol-lowering medications, significant residual cardiovascular risk related to atherosclerosis remains. Here, we explore whether the cytokine-like protein FAM3D contributes to atherosclerosis. Clinical cohort data reveal that elevated circulating FAM3D levels are strongly associated with human atherosclerosis. Both global and intestinal …

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Genome-Wide Association Uncovered SbERF60 Positively Regulates Mesocotyl Length in Sorghum

Lan Ju, Xiaoqiang Cheng, Yao Wang, R X Liu et autres

Mesocotyl length is a key factor affecting deep-seedling emergence and consequently influences grain yield in sorghum. However, at present, limited genes regulating mesocotyl elongation have been identified and the underlying molecular mechanisms remain unclear in sorghum. Here, we combined a genome-wide association …

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Engineered Escherichia coli Nissle 1917 for the High Level Biosynthesis of γ-Aminobutyric Acid

Junhao Yue, Wanting Wu, Fangfang Fan, Weirui Zhao et autres

γ-Aminobutyric acid (GABA), a vital bioactive component, is biosynthesized via the decarboxylation of L-glutamate (L-Glu) catalyzed by glutamate decarboxylase (GAD). However, the GADs from various sources commonly suffer from low thermal stability, which hampers their industrial applications. In this work, four ancestral …

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Uncovering the quality markers and mechanisms of Gastrodia elata against LPS-induced neuroinflammation via network pharmacology and experimental verification

Tao Chen, S. J. Tian, Lifang Cao, Ling Tao et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Gastrodia elata Blume (TM), a renowned traditional Chinese medicinal herb, has long been clinically used for the treatment of dizziness, stroke and other cerebrovascular diseases. Modern pharmacological investigations have confirmed that its neuroprotective effects are closely associated with the amelioration …

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CD2AP Positively Regulates TGF-β1/Smad3-Mediated EMT via TβRI: A Novel Oncogenic Axis Driving Hepatocellular Carcinoma Progression

Dexi Wang, Xinran Meng, Fangfang Fan, Dina Tuerhong et autres

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Single-cell transcriptomics reveals the ameliorative effect of gastrodin on cholestatic liver fibrosis

Di Pan, Tian Zheng, Canping Chen, Jie Qiu et autres

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