Isha Taneja

Women as Recipients of Recognition Awards from Medical Societies in the United States: A Systematic Review and Meta-Analysis

Isha Taneja, Amarilis A. Martin, Jeremy W. Jacobs, Emily M. Kent et autres

IMPORTANCE: Recognition awards from medical societies are a key marker of professional achievement and play a crucial role in physician career advancement. At many academic institutions, national honors-such as society-based recognition awards-are integral to the criteria for promotion to the rank of …

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Examining pre-analytical factors for bioanalysis of protein therapeutics crossing the blood–brain barrier through receptor-mediated transcytosis

Wenyu Li, Jun Chen, Isha Taneja, Wilson Barry Edwards et autres

BACKGROUND: The blood-brain barrier (BBB) poses challenges for delivering large-molecule therapeutics to the brain. While engineered cross-BBB delivering platforms such as antibodies utilizing receptor-mediated transcytosis (RMT) aim to improve drug delivery, accurate quantization of antibody exposure in the brain is critical. This …

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Validation of Food Frequency Questionnaire for Egg Protein Intake in Infants and Toddlers with Food Allergies

Hsiang-Ting Lin, Jane L. Hubbard, Isha Taneja, Shelby Oster et autres

Beyond Peanut: The Allergen Gap in Pediatric Practice

Lauren Davidson, Tanya M. Laidlaw, Isha Taneja, Hannah C. Martin et autres

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Industry Practices in Oligonucleotide Tissue Biodistribution Assessment: An IQ consortium Cross-Industry Survey of Current Approaches and Emerging Trends

Michael McCoy, Huaping Tang, Lydia Michaut, Irina Laczkovich et autres

Accurate assessment of tissue distribution for oligonucleotide therapeutic (ONT) drug candidates is essential for understanding pharmacokinetic behavior and predicting therapeutic efficacy. ONTs present a unique challenge with their rapid systemic clearance coupled with prolonged tissue retention, making comprehensive tissue concentration evaluation critical …

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A review on integrated machine learning and deep learning driven artificial intelligence models for pharmacokinetics and toxicokinetics predictions, and their application

M. Malarvannan, S. Monohar, Sanskruti Sitaram Kate, Isha Taneja et autres

The development of artificial intelligence (AI) tools and technology has made AI-driven drug discovery a more prominent field. We are firmly in the AI era, with hybrid designs that eventually comprise deep learning (DL) and conventional machine learning (ML). Although traditional models …

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Comparative Effectiveness of Medical Therapies for Locally Advanced Gastric Adenocarcinoma

Shazia Siddique, Benjamin Rouse, Abraham Segura, Shannon Ugarte et autres

Objectives. This systematic review (SR) aimed to evaluate the comparative effectiveness and harms of medical therapies for non-metastatic, locally advanced gastric adenocarcinoma to inform the development of an American Society of Clinical Oncology (ASCO) Clinical Practice Guideline. Specifically, the SR addressed (1) …

Authors of Clinical Practice Guidelines by Gender, Race, and Ethnicity: A Systematic Review and Meta-Analysis

Isha Taneja, Jeremy W. Jacobs, Fabrisia Ambrosio, Garrett S. Booth et autres

IMPORTANCE: Clinical practice guidelines (CPGs) play a critical role in shaping medical care and healthcare policies, yet there is growing concern about the lack of diversity in CPG authorship. This systematic review and meta-analysis aim to assess gender, race, and ethnicity representation …

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Predicting the in vivo developmental toxicity of fenarimol from in vitro toxicity data using PBTK modelling-facilitated reverse dosimetry approach

Manisha Bhateria, Isha Taneja, Kajal Karsauliya, Ashish Kumar Sonker et autres

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Identifying Cardiovascular System Involvement through Heart Rate Trends in Food-Induced Systemic Reactions in Infants and Toddlers

Lourdes Ramírez, Ian Roy, Isha Taneja, Samantha Yap et autres

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Discovery of JNJ-88549968, a Novel, First-in-Class CALRmutxCD3 T-Cell Redirecting Antibody for the Treatment of Myeloproliferative Neoplasms

Anna Kuchnio, Elsie Samakai, Eva Hug, Meritxell Balmaña et autres

Myeloproliferative neoplasms (MPNs) are clonal malignant disorders of hematopoiesis arising in the hematopoietic stem cell (HSC) compartment that are characterized by excessive production of mature blood cells of the myeloid lineage. Transformation to secondary acute myeloid leukemia (sAML) represents a significant cause …

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Frequency and predictors of multisystem reactions to peanut in infant oral food challenges

Corinne Allison Keet, Robert A. Wood, Jennifer A. Dantzer, Mihaela Plesa et autres

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