Lenore D. Pitstick

Longitudinal Single-Cell Analysis of Asbestos-Induced Pulmonary Fibrosis

Jonathan M. Franks, Yu Takahashi, Yuya Tanaka, Lenore D. Pitstick et autres

Abstract RATIONALE Asbestos-induced lung injury initiates a cascade of inflammation and fibrotic remodeling of the airway. The cellular and molecular events surrounding these events are not well understood. In this study, we performed a deep interrogation of the transcriptional changes following inhalation …

us (code pays fourni par la source)

The Effects of Photobiomodulation Therapy on Xenopus laevis Embryonic Epithelium

Kelsey R. Lloyd, Lenore D. Pitstick, Feng Gao, Maria Cuevas‐Nunez et autres

Background: Photobiomodulation therapy (PBMT) is widely used in clinical settings, particularly for treating oral mucositis. Although PBMT has shown promise in aiding tissue healing, its safety and potential effects on tumorigenesis remain controversial. Objective: Xenopus laevis ( X. laevis ) tadpoles have …

us, es (code pays fourni par la source)

Tail Tales: What We Have Learned About Regeneration from Xenopus Laevis Tadpoles

Jessica Lara, Camilla Mastela, Magda Abd, Lenore D. Pitstick et autres

This review explores the regenerative capacity of Xenopus laevis, focusing on tail regeneration, as a model to uncover cellular, molecular, and developmental mechanisms underlying tissue repair. X. laevis tadpoles provide unique insights into regenerative biology due to their regeneration-competent and -incompetent stages …

us (code pays fourni par la source)

Rho-Associated Protein Kinase Activity Is Required for Tissue Homeostasis in the Xenopus laevis Ciliated Epithelium

Fayhaa Khan, Lenore D. Pitstick, Jessica Lara, Rosa Ventrella

Lung epithelial development relies on the proper balance of cell proliferation and differentiation to maintain homeostasis. When this balance is disturbed, it can lead to diseases like cancer, where cells undergo hyperproliferation and then can undergo migration and metastasis. Lung cancer is …

us (code pays fourni par la source)

Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer

Lenore D. Pitstick, Joanna Góral, Mae J. Ciancio, Alice Meyer et autres

OBJECTIVES: To investigate the effects of dietary folate and sex on histopathology of oral squamous cell carcinoma in mice. MATERIALS AND METHODS: Mice (C57Bl/6, 30/sex) were fed either a deficient folate or sufficient folate diet. Vehicle or 4-nitroquinoline1-oxide (50 μg/mL) in vehicle …

us (code pays fourni par la source)

Fat and exposure to 4-nitroquinoline-1-oxide causes histologic and inflammatory changes in murine livers

Lenore D. Pitstick, Joanna Góral, Ryan A. Schmelter, Christine M. Fuja et autres

Risk factors for liver cancer include tobacco use, alcohol consumption, obesity, and male sex. Administration of 4-nitroquinonline-1-oxide (4NQO) in drinking water mimics the effects of tobacco and leads to oral carcinoma in mice. This study compared the effects of diets high and …

us (code pays fourni par la source)

Dietary folic acid deficiency impacts hippocampal morphology and cortical acetylcholine metabolism in adult male and female mice

Calli Bennett, Jacalyn M. Green, Mae J. Ciancio, Joanna Góral et autres

OBJECTIVE: One-carbon (1C) metabolism is a metabolic network that integrates nutritional signals with biosynthesis, redox homeostasis, and epigenetics. There are sex differences in hepatic 1C metabolism, however, it is unclear whether sex differences in 1C impact the brain. The aim of this …

us, ca (code pays fourni par la source)

Dietary folic acid deficiency impacts hippocampal morphology and cortical acetylcholine metabolism in adult male and female mice

Calli Bennett, Jacalyn M. Green, Mae J. Ciancio, Joanna Góral et autres

Abstract Objective One-carbon metabolism is a metabolic network that integrates nutritional signals with biosynthesis, redox homeostasis, and epigenetics. There are sex differences in hepatic one-carbon metabolism. However, it is unclear whether there are sex differences in dietary deficiencies of one-carbon metabolism in …

us, ca (code pays fourni par la source)

Dietary fat and male sex increase histopathological changes in a mouse model of oral cancer

Jacalyn M. Green, Mae J. Ciancio, Joanna Góral, Matthew Pytynia et autres

Abstract Objective To compare the effects of dietary fat and sex on murine oral squamous cell carcinoma pathology. Materials and methods Male and female C57Bl/6 mice (36/sex) received a low‐fat (10 kcal%) or high‐fat (60 kcal%) diet. Water (control), vehicle, or 4‐nitroquinoline‐1‐oxide …

us (code pays fourni par la source)

Comparison of High Fat and Low Fat Diets on Histopathological Changes in Liver in a Mouse Model of 4NQO‐induced Oral Cancer

Jacalyn M. Green, Lenore D. Pitstick, Joanna Góral, Ryan M. Schmelter et autres

Introduction Worldwide, liver cancer remains among the top ten most common cancers. Risk factors for liver cancer include tobacco usage, alcohol consumption, obesity, and sex. Administration of 4‐nitroquinoline 1‐oxide (4NQO) in drinking water mimics the effects of tobacco and leads to oral …

SPECC1L regulates palate development downstream of IRF6

Everett G. Hall, Luke W. Wenger, Nathan R. Wilson, Sraavya S Undurty-Akella et autres

SPECC1L mutations have been identified in patients with rare atypical orofacial clefts and with syndromic cleft lip and/or palate (CL/P). These mutations cluster in the second coiled-coil and calponin homology domains of SPECC1L and severely affect the ability of SPECC1L to associate …

us, jp, Nigéria, Éthiopie (code pays fourni par la source)

Dysregulation of Sphingolipid Metabolism in Pulmonary Lymphangioleiomyomatosis (LAM)

Jane J. Yu, Xiaohao Liu, C. Li, Lenore D. Pitstick et autres

us (code pays fourni par la source)