Dangsheng Li

Asymmetric RBBP7 regulates the first cell fate decision of early mammalian embryos

Lin-Fang Ju, Xiao Han, Danru Zhang, Heng-Ji Xu et autres

Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest protein factor regulating …

cn (code pays fourni par la source)

Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance

Qin Yongli, Jia Lina, Huijiao Liu, Ma Wenqiang et autres

In obesity, macrophages drive a low-grade systemic inflammation (LSI) and insulin resistance (IR). The ribosome biosynthesis protein NOC4 (NOC4) mediates 40 S ribosomal subunits synthesis in yeast. Hereby, we reported an unexpected location and function of NOC4L, which was preferentially expressed in …

cn, us, pl, fi (code pays fourni par la source)

RNA immunity: an ancient defense mechanism preserved in mammalian cells

Zheng Fu, Liang Li, Yanbo Wang, Xin Yin et autres

cn (code pays fourni par la source)

Data from KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

Peng Yuan, Xiaohong He, Yefei Rong, Jing Cao et autres

Abstract KRAS activation occurring in more than 90% of pancreatic ductal adenocarcinomas (PDAC) drives progression and metastasis, but the underlying mechanisms involved in these processes are still poorly understood. Here, we show how KRAS acts through inflammatory NF-κB signaling to activate the …

Supplemental Figures and table from KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

Peng Yuan, Xiaohong He, Yefei Rong, Jing Cao et autres

This file contains 6 figures (Supplementary Fig. S1-6) and 1 table (Supplementary Table S1). These figures and table provide additional, directly relevant, and unrepeated information for the article content. In brief, Supplementary Figures S1 and S3 indicate that miR-489 is an effector …

Supplemental Materials and Methods from KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

Peng Yuan, Xiaohong He, Yefei Rong, Jing Cao et autres

This file contains Materials and Methods that are involved in the figures of the main text and supplementary information. These materials and methods include information of plasmid constructs, cell transfection and viral transduction, RNA preparation and qRT-PCR, luciferase reporter assay, ChIP assay, …

Supplemental Figures and table from KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

Peng Yuan, Xiaohong He, Yefei Rong, Jing Cao et autres

This file contains 6 figures (Supplementary Fig. S1-6) and 1 table (Supplementary Table S1). These figures and table provide additional, directly relevant, and unrepeated information for the article content. In brief, Supplementary Figures S1 and S3 indicate that miR-489 is an effector …

Supplemental Materials and Methods from KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

Peng Yuan, Xiaohong He, Yefei Rong, Jing Cao et autres

This file contains Materials and Methods that are involved in the figures of the main text and supplementary information. These materials and methods include information of plasmid constructs, cell transfection and viral transduction, RNA preparation and qRT-PCR, luciferase reporter assay, ChIP assay, …

Data from KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

Peng Yuan, Xiaohong He, Yefei Rong, Jing Cao et autres

Abstract KRAS activation occurring in more than 90% of pancreatic ductal adenocarcinomas (PDAC) drives progression and metastasis, but the underlying mechanisms involved in these processes are still poorly understood. Here, we show how KRAS acts through inflammatory NF-κB signaling to activate the …

Data from The Nuclear Receptor Interacting Factor-3 Transcriptional Coregulator Mediates Rapid Apoptosis in Breast Cancer Cells through Direct and Bystander-Mediated Events

Sharmistha Das, Jerome C. Nwachukwu, Dangsheng Li, Anthony I. Vulin et autres

Abstract We previously reported that amino acids 20 to 50 of nuclear receptor interacting factor-3 mediates rapid apoptosis in breast cancer cell lines but not in cells derived from other tissues. We refer to this short region as death domain-1 (DD1). Small …

Data from The Nuclear Receptor Interacting Factor-3 Transcriptional Coregulator Mediates Rapid Apoptosis in Breast Cancer Cells through Direct and Bystander-Mediated Events

Sharmistha Das, Jerome C. Nwachukwu, Dangsheng Li, Anthony I. Vulin et autres

Abstract We previously reported that amino acids 20 to 50 of nuclear receptor interacting factor-3 mediates rapid apoptosis in breast cancer cell lines but not in cells derived from other tissues. We refer to this short region as death domain-1 (DD1). Small …

Supplementary Movie 1 from The Nuclear Receptor Interacting Factor-3 Transcriptional Coregulator Mediates Rapid Apoptosis in Breast Cancer Cells through Direct and Bystander-Mediated Events

Sharmistha Das, Jerome C. Nwachukwu, Dangsheng Li, Anthony I. Vulin et autres

Supplementary Movie 1 from The Nuclear Receptor Interacting Factor-3 Transcriptional Coregulator Mediates Rapid Apoptosis in Breast Cancer Cells through Direct and Bystander-Mediated Events