Rosanna Gissi

OPA1 drives macrophage metabolism and functional commitment via p65 signaling

Ricardo Sánchez‐Rodríguez, Caterina Tezze, Andrielly H.R. Agnellini, Roberta Angioni et autres

Macrophages are essential players for the host response against pathogens, regulation of inflammation and tissue regeneration. The wide range of macrophage functions rely on their heterogeneity and plasticity that enable a dynamic adaptation of their responses according to the surrounding environmental cues. …

it, ca (code pays fourni par la source)

The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration

Simona Feno, Fabio Munari, Denis Vecellio Reane, Rosanna Gissi et autres

Damaged skeletal muscle can regenerate because of the coordinated action of immune cells with muscle stem cells, called satellite cells. Proinflammatory macrophages infiltrate skeletal muscle soon after injury to sustain the proliferation of satellite cells. These macrophages later acquire the anti-inflammatory phenotype …

it, fr (code pays fourni par la source)

N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages

Alessio Menga, Maria Favia, Iolanda Spera, Maria Carmela Vegliante et autres

Glutaminolysis is known to correlate with ovarian cancer aggressiveness and invasion. However, how this affects the tumor microenvironment is elusive. Here, we show that ovarian cancer cells become addicted to extracellular glutamine when silenced for glutamine synthetase (GS), similar to naturally occurring …

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Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages

Alessio Menga, Marina Serra, Simona Todisco, Carla Riera‐Domingo et autres

Glutamine synthetase (GS) generates glutamine from glutamate and controls the release of inflammatory mediators. In macrophages, GS activity, driven by IL10, associates to the acquisition of M2-like functions. Conditional deletion of GS in macrophages inhibits metastasis by boosting the formation of anti-tumor, …

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Pharmacological targets of metabolism in disease: Opportunities from macrophages

Alessandra Castegna, Rosanna Gissi, Alessio Menga, Monica Montopoli et autres

it (code pays fourni par la source)

Monoamine oxidase-dependent histamine catabolism accounts for post-ischemic cardiac redox imbalance and injury

Veronica Costiniti, Iolanda Spera, Roberta Menabò, Erika M. Palmieri et autres

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Histamine catabolism contributes to cardiac injury by sustainingmonoamine oxidase-dependent oxidative stress

Rosanna Gissi, Veronica Costiniti, Iolanda Spera, Roberta Menabò et autres