Karl Tryggvason

Spatiotemporal Transcriptomics of Human Cardiovascular Progenitors in Pig Hearts Identifies MIDKINE as a Positive Regulator of Neovascularization

Lynn Yap, Swarnaseetha Adusumalli, Samantha Lim, Vincent Ren et autres

sg, au, dk, us (code pays fourni par la source)

10012: Spatially Resolved Atlas of Transplanted Human Cardiac Progenitors Reveals Post-Infarct Cardiac Regeneration and Cellular Maturation

Swarnaseetha Adusumalli, Samantha Lim, Vincent Ren, Li Yen Chong et autres

The Protective Role of KANK1 in Podocyte Injury

Keiko Oda, Kan Katayama, Liqing Zang, Masaaki Toda et autres

Approximately 30% of steroid-resistant nephrotic syndromes are attributed to monogenic disorders that involve 27 genes. Mutations in KANK family members have also been linked to nephrotic syndrome; however, the precise mechanism remains elusive. To investigate this, podocyte-specific Kank1 knockout mice were generated …

jp, se (code pays fourni par la source)

The Protective Role of KANK1 in Podocyte Injury

Keiko Oda, Kan Katayama, Liqing Zang, Masaaki Toda et autres

Approximately 30% of steroid-resistant nephrotic syndromes are attributed to monogenic disorders that involve 27 genes. Mutations in KANK family members have also been linked to nephrotic syndrome; however, the precise mechanism remains elusive. To investigate this, podocyte-specific Kank1 knockout mice were generated …

jp, se (code pays fourni par la source)

Periportal macrophages protect against commensal-driven liver inflammation

Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa et autres

jp, sg (code pays fourni par la source)

Skin mesenchymal niches maintain and protect AML-initiating stem cells

Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao et autres

Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin …

se (code pays fourni par la source)

Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs

Lynn Yap, Li Yen Chong, Clarissa Tan, Swarnaseetha Adusumalli et autres

Ischemic heart disease, which is often associated with irreversibly damaged heart muscle, is a major global health burden. Here, we report the potential of stem cell-derived committed cardiac progenitors (CCPs) have in regenerative cardiology. Human pluripotent embryonic stem cells were differentiated to …

sg, us, se (code pays fourni par la source)

Photoreceptor laminin drives differentiation of human pluripotent stem cells to photoreceptor progenitors that partially restore retina function

Hwee Goon Tay, Helder André, Vicki Chrysostomou, Swarnaseetha Adusumalli et autres

Blindness caused by advanced stages of inherited retinal diseases and age-related macular degeneration are characterized by photoreceptor loss. Cell therapy involving replacement with functional photoreceptor-like cells generated from human pluripotent stem cells holds great promise. Here, we generated a human recombinant retina-specific …

sg, se, us (code pays fourni par la source)

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

Rhea Nadkarni, Wern Cui Chu, Cheryl Q. E. Lee, Yasir Mohamud et autres

Nucleotide-binding oligomerization domain (NBD), leucine-rich repeat (LRR) containing protein family (NLRs) are intracellular pattern recognition receptors that mediate innate immunity against infections. The endothelium is the first line of defense against blood-borne pathogens, but it is unclear which NLRs control endothelial cell …

sg, ca (code pays fourni par la source)

A high-resolution map of human RNA translation

Sonia Pankaj Chothani, Eleonora Adami, Anissa Anindya Widjaja, Sarah R. Langley et autres

sg, de, gb, au (code pays fourni par la source)

Skin mesenchymal niches maintain and protect AML-initiating stem cells

Lakshmi Sandhow, Huan Cai, Elory Leonard, Pingnan Xiao et autres

Abstract Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the …

se (code pays fourni par la source)

Pluripotent Stem Cell-Derived Cardiovascular Progenitors Regenerate and Improve Function of Infarcted Pig Hearts

Lynn Yap, Li Yen Chong, Clarissa Tan, Swarnaseetha Adusumalli et autres

sg (code pays fourni par la source)