Lucia Lauková

The Latin Version of the Eleventh Revision of the International Classification of Diseases: The Process of Translation and its Pedagogical Implications

Tomáš Hamar, Alyssa Bryl, Lucia Lauková, Melinda Vasiľová

The International Classification of Diseases, ICD-11, is now officially in effect for national and international recording and reporting of causes of illness, death, and other information. The ICD provides a common language that allows healthcare professionals to share standardised information worldwide. The …

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Infection with SARS-CoV-2 Is Associated with Elevated Levels of IP-10, MCP-1, and IL-13 in Sepsis Patients

Tanja Eichhorn, Silke Huber, René Weiss, Marie Ebeyer-Masotta et autres

Immunothrombosis, an excessive inflammatory response with simultaneous overactivation of the coagulation system, is a central pathomechanism in sepsis and COVID-19. It is associated with cellular activation, vascular damage, and microvascular thrombosis, which can lead to multiple organ failure and death. Here, we …

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Targeting the Structural Integrity of Extracellular Vesicles via Nano Electrospray Gas-Phase Electrophoretic Mobility Molecular Analysis (nES GEMMA)

Stephanie Steinberger, Sobha Karuthedom George, Lucia Lauková, René Weiss et autres

Extracellular vesicles (EVs) are in the scientific spotlight due to their potential application in the medical field, ranging from medical diagnosis to therapy. These applications rely on EV stability during isolation and purification-ideally, these steps should not impact vesicle integrity. In this …

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Activated Platelets and Platelet-Derived Extracellular Vesicles Mediate COVID-19-Associated Immunothrombosis

Marie Ebeyer-Masotta, Tanja Eichhorn, René Weiss, Lucia Lauková et autres

Activated platelets and platelet-derived extracellular vesicles (EVs) have emerged as central players in thromboembolic complications associated with severe coronavirus disease 2019 (COVID-19). Platelets bridge hemostatic, inflammatory, and immune responses by their ability to sense pathogens via various pattern recognition receptors, and they …

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Variability of endogenous deoxyribonuclease activity and its pathophysiological consequences

Ľubica Janovičová, Jozef Čonka, Lucia Lauková, Peter Celec

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Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and Histones

Marie Ebeyer-Masotta, Tanja Eichhorn, René Weiss, Vladislav Semak et autres

Inflammation and thrombosis are closely intertwined in numerous disorders, including ischemic events and sepsis, as well as coronavirus disease 2019 (COVID-19). Thrombotic complications are markers of disease severity in both sepsis and COVID-19 and are associated with multiorgan failure and increased mortality. …

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A possible role of gas-phase electrophoretic mobility molecular analysis (nES GEMMA) in extracellular vesicle research

Stephanie Steinberger, Sobha Karuthedom George, Lucia Lauková, René Weiss et autres

The emerging role of extracellular vesicles (EVs) as biomarkers and their envisioned therapeutic use require advanced techniques for their detailed characterization. In this context, we investigated gas-phase electrophoresis on a nano electrospray gas-phase electrophoretic mobility molecular analyzer (nES GEMMA, aka nES differential …

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Comparative Analysis of Platelet-Derived Extracellular Vesicles Using Flow Cytometry and Nanoparticle Tracking Analysis

Sobha Karuthedom George, Lucia Lauková, René Weiss, Vladislav Semak et autres

Growing interest in extracellular vesicles (EVs) has prompted the advancements of protocols for improved EV characterization. As a high-throughput, multi-parameter, and single particle technique, flow cytometry is widely used for EV characterization. The comparison of data on EV concentration, however, is hindered …

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Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors

Tanja Eichhorn, Ingrid Linsberger, Lucia Lauková, Carla Tripisciano et autres

The timely recognition of sepsis and the prediction of its clinical course are challenging due to the complex molecular mechanisms leading to organ failure and to the heterogeneity of sepsis patients. Treatment strategies relying on a “one‐fits‐all” approach have failed to reduce …

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Biological Anti‐TNF‐α Therapy and Markers of Oxidative and Carbonyl Stress in Patients with Rheumatoid Arthritis

Emὄke Šteňová, Martina Bakošová, Lucia Lauková, Peter Celec et autres

Rheumatoid arthritis (RA) as a chronic inflammatory disease is associated with oxidative stress. Drugs targeting tumor necrosis factor‐alpha (TNF‐α) ameliorate inflammation and symptoms of RA in most patients. Whether markers of oxidative stress can be used for monitoring of treatment effects is …

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Desialylation of platelet surface glycans enhances platelet adhesion to adsorbent polymers for lipoprotein apheresis

Lucia Lauková, René Weiss, Vladislav Semak, Viktoria Hoffmann Weber

BACKGROUND: Lipoprotein apheresis is an important therapeutic option in homozygous familial hypercholesterolemia, progressive atherosclerosis, or when depletion of lipoprotein(a) is indicated. It is generally regarded as safe, but drops in platelet counts as well as sporadic episodes of thrombocytopenia have been reported. …

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Deoxyribonucleases and Their Applications in Biomedicine

Lucia Lauková, Barbora Konečná, Ľubica Janovičová, Barbora Vlková et autres

Extracellular DNA, also called cell-free DNA, released from dying cells or activated immune cells can be recognized by the immune system as a danger signal causing or enhancing inflammation. The cleavage of extracellular DNA is crucial for limiting the inflammatory response and …

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