Figure S3 from BRD9 Degraders Unleash GBAF Chromatin Remodeling Activity in Synovial Sarcoma

Le résumé fourni par la source

Supplemental Figure S3 (associated with Figure 3). WA-68 is variably efficacious against SyS in vivo. A. Necropsy CDX harvest photos from treated MoJo xenografts (mm scaled markings included). B. Harvest photos from treated HS-SY-II CDXs (mm scaled markings included). C. Harvest photos from treated STG048 (magnification bar indicates 2 mm). D. Harvest photos from treated JC2621 (magnification bar indicates 2 mm). E. Representative photomicrographs of hematoxylin and eosin stained (H&E) histology sections from treated MoJo CDXs (magnification bars are 50µm in length). F. The same from HS-SY-II CDXs, showing slightly more spindled cell morphology after WA-68. G. The same from STG017 PDXs, showing increased round cell morphology after WA-68. H. The same from STG048 PDXs, showing increased spindled morphology after WA-68, but no frank necrosis (black magnification bars are 50µm in length; white magnification bar is 2mm in length). I. The same from JC2621 PDXs, showing rounder cell morphology after WA-68, and no frank necrosis (same magnification bars). J. Mid-coronal images from the fluorothymidine PET/MR imaging, showing tumor on the left flank that is FLT avid, T2 hyperintense, and T1 hypointense.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.