Effect of Topically Administered Natural Compounds on Cesarean Section Healing—A Retrospective Observational Study

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Natural compounds in topical gel formulations are recognized for their ability to enhance wound healing, particularly in the context of postoperative care, including that of cesarean sections. Background: Cesarean sections are among the most common surgical procedures globally, highlighting the importance of their successful healing. Complementary medicine aimed at pain relief and wound healing after a cesarean section has been investigated worldwide, and natural compounds are considered safe for topical use during pregnancy and breastfeeding. The aim of our study is to demonstrate the efficacy of the use of natural compounds in post-cesarean scar treatment. Materials and Methods: We compared Reparis, a topical gel entirely composed of natural compounds such as Centella asiatica and Aloe vera, with Cicatridine, a topical gel containing synthetic and natural compounds, such as almond oil, in post-cesarean wound treatment. We conducted an observational retrospective study in County Hospital Hunedoara between 26 February and 31 May 2026, evaluating specific measures that relate to the cosmetic results of scars after surgical procedures in our unit, with 50 patients using Reparis twice a day compared to the control group, which itself consisted of 50 patients using Cicatridine twice a day for 30 days. We employed the POSAS, an internationally validated questionnaire for evaluating patient and surgeon opinions regarding the appearance of a scar. Results: The most important difference favoring Reparis was observed after 6 months (p = 0.0001). In addition, Cicatridine exhibits a positive correlation with BMI; Reparis can be used in cases of higher BMI with good healing results. Conclusions: Natural compounds alone, such as Reparis, pose promising potential for wound healing, based on the findings of our observational study. The therapeutic properties of traditional medical plants have been verified but not always in controlled clinical trials. Our findings still require external validation.

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