Cardiac Myosin-Binding Protein C in Cardiovascular Disease
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Cardiac myosin-binding protein C (cMyBPC) is an important sarcomeric regulatory protein that plays a key role in myocardial contraction and relaxation. Through its interactions with thick and thin filament proteins, cMyBPC helps regulate cross-bridge cycling and contributes significantly to overall cardiac performance. Alterations in its expression, structure, or phosphorylation state have been associated with several forms of cardiovascular disease. Pathogenic variants in the MYBPC3 gene represent one of the most common genetic causes of hypertrophic cardiomyopathy (HCM). These mutations have been implicated in the disruption of normal sarcomeric function, altered contractility, and subsequent ventricular remodeling. Although significant progress has been made in understanding the relationship between MYBPC3 mutations and HCM, the mechanisms by which individual variants lead to specific clinical phenotypes remain incompletely understood. Beyond its role in sarcomeric regulation, cMyBPC has emerged as a potential biomarker of myocardial injury. Studies have demonstrated that fragments of the protein are released into the circulation following ischemic damage, raising interest in its potential use as an adjunctive marker for the early detection of acute myocardial infarction. This review provides an overview of the molecular biology and physiologic functions of cMyBPC and examines its role in HCM, myocardial injury, and other forms of cardiovascular disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cardiac Myosin-Binding Protein C in Cardiovascular Disease
- Date Crossref
- 28/08/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Northwell Health pays non établi dans la noticeÉtablissement de santé
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Donald & Barbara Zucker School of Medicine at Hofstra/Northwell pays non établi dans la noticeUniversité ou école supérieure
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Nassau University Medical Center Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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Westchester Medical Center Departments of Medicine pays non établi dans la noticeÉtablissement de santé
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New York Medical College pays non établi dans la noticeUniversité ou école supérieure
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Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Northwell Cardiovascular Institute Department of Medicine pays non établi dans la noticeStructure de recherche
Northwell Health, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell et Department of Cardiology — Nassau University Medical Center, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.