Effect of CT-based material grouping on finite element strength and stiffness predictions in vertebrae with metastatic lesions
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Le résumé fourni par la source
Abstract Introduction Metastatic spinal lesions substantially alter vertebral mechanical properties and increase fracture risk. Computed tomography (CT)-based finite element (FE) models can estimate vertebral strength, but their accuracy depends on how CT-derived material properties are represented. This study evaluated the effect of two material-grouping strategies on simulated strength and stiffness in metastatic vertebrae. Methods We compared Adaptive Clustering (AC) with Uniform fixed-width grouping in 44 vertebrae from 11 donors (8 osteolytic, 12 osteoblastic, 12 mixed, 12 no observed lesion (NOL)). FE models were generated based on CT scans with 2–500 material groups and compared for material-mapping error and simulated strength and stiffness. Overall and lesion-stratified agreement with experimental measurements was assessed in an exploratory analysis. Results AC showed significantly lower Young’s modulus root-mean-square error than Uniform (p < 0.05). Simulated strength and stiffness stabilised by 50 material groups. At 50 groups, simulated strength showed moderate correlation with experimental strength overall (R² = 0.57), strongest in NOL vertebrae (R² = 0.82) and lower in lesion-bearing vertebrae (R² = 0.41–0.59). Stiffness showed weaker correlation overall (R² = 0.27), highest in NOL vertebrae (R² = 0.48) and negligible in mixed lesions (R² = 0.007). Bland-Altman analyses indicated systematic underestimation of experimental fracture load. Discussion AC improved material-mapping fidelity, whereas increasing material groups beyond 50 had little influence on simulated strength or stiffness. Numerical stabilisation therefore did not imply experimental accuracy. Lesion-stratified findings were exploratory and should be interpreted cautiously because of limited subgroup sizes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effect of CT-based material grouping on finite element strength and stiffness predictions in vertebrae with metastatic lesions
- Date Crossref
- 24/08/2026
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Beth Israel Deaconess Medical Center Department of Orthopedic Surgery pays non établi dans la noticeÉtablissement de santé
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Aarhus University Department of Mechanical and Production Engineering pays non établi dans la noticeUniversité ou école supérieure
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Deaconess Hospital pays non établi dans la noticeÉtablissement de santé
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Technical University of Munich pays non établi dans la noticeUniversité ou école supérieure
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Massachusetts Institute of Technology Department of Mechanical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Harvard Medical School pays non établi dans la noticeInstitution
Department of Orthopedic Surgery — Beth Israel Deaconess Medical Center, Department of Mechanical and Production Engineering — Aarhus University et Deaconess Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.