[In vivo study of posterior cruciate ligament reconstruction augmented by a novel elastic internal tension-relieving augmentation tape in Diannan miniature pigs].

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Objective: To explore the biosafety of a novel elastic internal tension-relieving augmentation tape (hereinafter referred to as "novel tension-relieving tape") for posterior cruciate ligament (PCL) reconstruction and its regulatory effects on graft healing and tendon-bone integration via a Diannan miniature pig PCL reconstruction model. Methods: =9): autologous tendon combined with the novel tension-relieving tape was applied in tension-relieving group, while only autologous tendon was used in non-tension-relieving group; the contralateral hind limb was served as self-normal control. Postoperative general conditions of animals were observed, and complete blood count (CBC) tests were performed. Knee joint specimens were harvested at 3, 6, and 12 months postoperatively for gross observation and Marburger Arthroscopy Score (MAS) evaluation. Toluidine blue staining, safranin O-fast green staining, hematoxylin-eosin (HE) staining, collagen type Ⅰ/Ⅲ immunohistochemistry staining, and Sirius red staining were conducted to assess tendon-bone interface healing. HE staining of liver, lung, spleen, and the tissues around tendon-bone implantation area were performed to evaluate the biosafety of the material. Results: >0.05). Conclusion: The novel tension-relieving tape possesses reliable biosafety. It can effectively accelerate early graft collagen remodeling and tendon-bone interface healing after PCL reconstruction, and improve early knee joint stability.

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