Non-interventional multicenter study of the management of patients with non-radiographic axial spondyloarthritis in real-world clinical practice in the Russian Federation (NiSpAR): data from the prospective part
Rattachement africain : ru. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
In the Russian Federation, there is an unmet need for research of non-radiographic (nr) axial spondyloarthritis (nr-axSpA). Therefore, the noninterventional multicenter NiSpAR study was initiated in 2022. Objective: to describe a cohort of patients with nr-axSpA and approaches to its diagnosis in the Russian Federation. Material and methods . The study involved 20 research centers from different regions of the Russian Federation. The article presents the results of prospective follow-up. Of 272 screened patients with a preliminary diagnosis of nr-axSpA, 113 (41.5%) met the 2009 ASAS criteria. The mean age of the patients was 37.1±11.2 years, and the median disease duration was 17 [5; 60] months. The proportion of participants with a diagnosis duration of <2 years was 54.6%. More than half of the patients were male (52.2%). HLA-B27 positivity was detected in 70.8% of cases. The mean BASDAI and ASDAS-CRP scores were 3.6±2.0 and 2.7±0.9, respectively. Before inclusion in the study, the vast majority of patients received nonsteroidal anti-inflammatory drugs (94.7%), predominantly coxibs (55.5%); the synthetic disease-modifying antirheumatic drugs (DMARDs) sulfasalazine and methotrexate were used in 20.4 and 9.7%, respectively, systemic glucocorticoids in 3.5%, and biologic diseasemodifying antirheumatic drugs (bDMARDs) 9.7%. Results and discussion . Objective signs of inflammation were present in 85 (75.2%) patients; active sacroiliitis was detected by magnetic resonance imaging in 77 (68.1%), and elevated serum CRP levels were found in 40 (35.4%). During the 104 weeks of the study, a significant decrease in nr-axSpA activity according to the ASDAS and BASDAI indices was observed. Positive changes in CRP levels were noted, with the median decreasing 2.5-fold compared with baseline. The number of patients with very high nr-axSpA activity decreased almost 7-fold and that of patients with high activity decreased 1.7-fold; correspondingly, the proportion of patients with inactive disease increased, reaching a maximum of 60% at visit 3. The size of the group with low disease activity remained virtually unchanged by the end of follow-up. At the end of follow-up, radiographic axSpA/ankylosing spondylitis was diagnosed in 12 (10.6%) participants. The number of patients receiving bDMARDs increased to 14 (12.3%) by the end of the study. At baseline, physicians considered that 64.6% of patients required bDMARDs; this proportion was 20–30% by visit 2 and at subsequent visits. Conclusion . The results of the prospective stage of the study showed that, in real-world clinical practice, there is a continuing positive trend toward improved diagnosis of nr-axSpA, including its early forms with a duration of axial symptoms of up to 2 years. Treatment tactics are consistent with international standards. At the same time, there are limitations in prescribing bDMARDs and targeted synthetic DMARDs (tsDMARDs) to all patients who require them, which necessitates improved access to treatment in order to reduce the medical, social, and economic burden of axSpA in Russia.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Non-interventional multicenter study of the management of patients with non-radiographic axial spondyloarthritis in real-world clinical practice in the Russian Federation (NiSpAR): data from the prospective part
- Date Crossref
- 17/08/2026
- Éditeur
- IMA Press, LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Russian Medical Academy of Continuous Professional Education pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Health of the Russian Federation pays non établi dans la noticeOrganisme public
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The First Republican Clinical Hospital of the Ministry of Health of the Udmurt Republic pays non établi dans la noticeÉtablissement de santé
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Kazan State Medical University pays non établi dans la noticeUniversité ou école supérieure
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Ulyanovsk Regional Clinical Hospital pays non établi dans la noticeÉtablissement de santé
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Orenburg Regional Clinical Hospital №2 pays non établi dans la noticeÉtablissement de santé
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Tyumen Regional Oncological Dispensary pays non établi dans la noticeÉtablissement de santé
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Krasnoyarsk State Medical University pays non établi dans la noticeUniversité ou école supérieure
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Saratov State Medical University pays non établi dans la noticeUniversité ou école supérieure
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Krasnoyarsk Regional Clinical Hospital pays non établi dans la noticeÉtablissement de santé
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Institute of Clinical and Experimental Lymphology pays non établi dans la noticeStructure de recherche
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Novosibirsk State Medical University pays non établi dans la noticeUniversité ou école supérieure
Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation et The First Republican Clinical Hospital of the Ministry of Health of the Udmurt Republic, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.