Course of Portal Hypertension and Its Prognostic Impact After Liver Transplantation
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Le résumé fourni par la source
BACKGROUND: While portal hypertension (PH) typically resolves after liver transplantation (LT), persistence of PH may affect post-transplant outcomes. We assessed the evolution of PH after LT and its impact on adverse outcomes. METHODS: We recorded clinical, laboratory, and imaging parameters of LT recipients between 2016 and 2022 in Vienna and Zagreb. Persistent features of CSPH were defined as the presence of portosystemic collaterals, platelet count (PLT) ≤ 110 G/L, and/or splenomegaly (≥ 13 cm). PH-related clinical events were defined as variceal bleeding, ascites requiring intervention, hepatic hydrothorax, portal vein thrombosis, or liver-related death within 12 months post-LT. Post-LT outcomes were analyzed using landmark Cox regression for 3 months post-LT. RESULTS: Of 645 LT recipients (76% male, median age 59 years) listed with a median MELD of 15 points and PLT of 99 G/L, features of CSPH were present in 537 (83.3%) at baseline. At year 1 after LT, MELD improved to 9 (IQR 7-12), PLT increased to 160 G/L (IQR 120-207), and features of CSPH persisted in 251/453 classifiable patients (55.4%). PH events occurred in 75 (11.6%) and 84 (13%) deaths. In a landmark analysis from 3 months post-LT (n = 521, 29 deaths), persistent thrombocytopenia (< 110 G/L) at M3 independently predicted mortality (aHR 2.31, 95% CI 1.01-5.30, p = 0.048) after adjustment for MELD, age, CRP, and pre-LT TIPS. CONCLUSIONS: While PH improves after LT, features of CSPH persisted in 55% of classifiable patients and PH-related clinical events occurred in 11.6% within the first year after LT. Persistent thrombocytopenia (< 110 G/L) at 3 months post-LT independently predicted post-LT mortality (aHR 2.31, 95% CI 1.01-5.30, p = 0.048).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Course of Portal Hypertension and Its Prognostic Impact After Liver Transplantation
- Date Crossref
- 08/08/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Medical University of Vienna pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Dubrava pays non établi dans la noticeÉtablissement de santé
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University Hospital Centre Zagreb pays non établi dans la noticeÉtablissement de santé
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Klinička bolnica Merkur pays non établi dans la noticeÉtablissement de santé
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Department of Gastroenterology and Hepatology School of Medicine University Hospital Merkur University of Zagreb Zagreb Croatia pays non établi dans la noticeUniversité ou école supérieure
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Department of Surgery Division of Transplantation University Hospital Merkur Zagreb Croatia pays non établi dans la noticeUniversité ou école supérieure
Medical University of Vienna, University Hospital Dubrava et University Hospital Centre Zagreb, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.