Michael Trauner

Intestinal barrier dysfunction assessed by confocal laser endomicroscopy correlates with cirrhosis severity and clinical outcome☆

Benedikt Simbrunner, Marcel Sorribas, Jessica Schaerer, Marco Felber et autres

BACKGROUND & AIMS: Intestinal barrier dysfunction drives complications in advanced chronic liver disease (ACLD). Confocal laser endomicroscopy (CLE) enables direct visualization of transepithelial fluorescein leakage during endoscopy. This study evaluated the link between CLE-assessed intestinal permeability and disease severity in ACLD. METHODS: …

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THU-505-YI Decreases in spleen stiffness assessed via vibration-controlled transient elastography at 100 Hz upon chronic NSBB treatment do not predict HVPG response: results from a european multicenter study

Paul Thöne, Dario Saltini, Joana Calvao, Maria Grazia Grasso et autres

Treatment patterns of eosinophilic esophagitis in the biologic era—a real-world analysis

Jagoda Pokryszka, Michael Weitersberger, Patrick Dinkhauser, Karin Steidl et autres

Eosinophilic esophagitis is a chronic immune-mediated disease requiring a long-term maintenance treatment. The data on therapy patterns and treatment durability in the biologic era are scarce in a real-world setting. The aim of this project was to provide information on the treatment …

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Fiber enrichment is not superior to dietary monitoring in MASLD: A dual-center, double-blind, placebo-controlled trial

Annette Brandt, Timur Yergaliyev, Emina Halibasic, Aline Cyba et autres

Dietary fiber enrichment may modulate intestinal microbiota and positively impact metabolic dysfunction-associated steatotic liver disease (MASLD). This randomized, double-blind, placebo-controlled dual-center study evaluated the effects of dietary fiber (oat bran and spelt bran) on MASLD. After a 3-week Run-in phase during which …

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Indocyanine Green Clearance Correlates With Biomarkers Reflecting Key Disease‐Driving Mechanisms in Advanced Chronic Liver Disease and Predicts Acute‐on‐Chronic Liver Failure and Death

Mathias Jachs, Tânia Carvalho, Benedikt Simbrunner, Georg Semmler et autres

BACKGROUND: Indocyanine green (ICG) clearance, determined by venous sampling, has shown promising results in the diagnosis of clinically significant portal hypertension (CSPH) in compensated advanced chronic liver disease (cACLD) and prognostication in decompensated ACLD (decompensated cirrhosis). Data on ICG clearance measurement by …

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Impact of Underlying Portal Hypertension on Severity and Course of Acute‐On‐Chronic Liver Failure

Vlad Țâru, Georg Kramer, Benedikt Silvester Hofer, Nina Dominik et autres

BACKGROUND AND AIMS: The impact of portal hypertension (PH) during acute-on-chronic liver failure (ACLF) remains unclear. This study investigated the link between underlying PH severity, systemic inflammation (SI), and the course of ACLF. METHODS: Consecutive patients with ACLF (n = 192) who …

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Neutrophil Extracellular Traps Are Not Linked to Decompensation, ACLF , or Death in Clinically Stable Patients With ACLD

Lorenz Balcar, Bernhard Scheiner, Benedikt Simbrunner, Mathias Jachs et autres

BACKGROUND AND AIMS: Neutrophil extracellular traps (NETs) are part of the body's innate immune response. In animal models, NETs aggravated liver injury and promoted disease progression/portal hypertension by the formation of (micro)thrombi leading to parenchymal extinction. This study aimed to investigate NETosis …

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Effectiveness of controlled-expansion transjugular intrahepatic portosystemic shunt (CX-TIPS) in an interdisciplinary setting at a large tertiary center

Marlene Hintersteininger, Theresa Müllner-Buscics, Susanne Riegler, Nina Dominik et autres

INTRODUCTION: The use of controlled-expansion transjugular intrahepatic portosystemic shunt (CX-TIPS) effectively controls portal hypertension (PH)-related complications while reducing risks related to fully expanded stents. We evaluated the effectiveness of CX-TIPS in a large Viennese patient cohort. METHOD: We assessed the number of …

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Smoking Aggravates Inflammation, Fibrogenesis, Angiogenesis and Cancer Risk in Patients With Cirrhosis

Nina Dominik, Benedikt Simbrunner, Bernhard Scheiner, Michael Schwarz et autres

BACKGROUND AND AIMS: Smoking induces a proinflammatory state, yet its role in advanced chronic liver disease (ACLD) remains understudied. This study evaluated its impact on disease-driving mechanisms and clinical outcomes in ACLD patients. METHODS: ACLD patients undergoing hepatic venous pressure gradient measurements …

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Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models

Thomas Sorz, Ksenia Brusilovskaya, Philipp Königshofer, Benedikt Silvester Hofer et autres

The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine-monophosphate (cGMP) pathway is impaired in liver fibrosis. We investigated expression patterns of NO-sGC-cGMP components via RT-qPCR in various rat models of liver fibrosis and murine models of liver fibrosis regression. Hepatic cGMP-levels were measured …

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The Vasopressin Biomarker Copeptin Is Linked to Systemic Inflammation and Refines Prognostication in Decompensated Cirrhosis

Lukas Hartl, Marlene Hintersteininger, Benedikt Simbrunner, Mathias Jachs et autres

BACKGROUND & AIMS: Copeptin, an arginine-vasopressin biomarker, may confer prognostic information in patients with advanced chronic liver disease (ACLD). METHODS: Patients with ACLD included in the Vienna Cirrhosis Study (NCT03267615) between January 2017 and April 2023 and available copeptin levels were prospectively …

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Acute liver failure in patients admitted to the intensive care unit—a Viennese retrospective single-center analysis

Patrick Haselwanter, Seanna Fairfield, Marlene Riedl-Wewalka, Monika Schmid et autres

BACKGROUND: Acute liver failure (ALF) is characterized by a rapid deterioration of liver function and a high mortality without transplantation depending on etiology and onset. Immediate transfer to a dedicated intensive care unit (ICU) and evaluation for high-urgency liver transplantation (HU-LTx) is …

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