Supplementary Figures S1-S12 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Le résumé fourni par la source

Fig. S1 | Cohort overview Fig. S2 | Study quality control overview Fig. S3 | Mass spectrometry performance across processing batches Fig. S4 | Intra-patient regional variation in TP53 and DCLK1 protein abundance Fig. S5 | Distinct protein abundance patterns across pancreatic tumorigenesis Fig. S6 | Detailed protein abundance patterns associated with key molecular programs underlying the cancer field effect and multistep pancreatic neoplasia Fig. S7 | Metabolic reprogramming in PanIN lesions Fig. S8 | PDAC lineage markers across the investigated trajectory Fig. S9 | Integration of spatial proteomics and transcriptomics data on the PDAC tumorigenesis Fig. S10 | Orthogonal validation of protein markers by multiplex immunofluorescence (mIF) staining Fig. S11 | Proteomics- and digital droplet PCR (ddPCR)-based identification of altered KRAS peptides Fig. S12 | Systematic exploration of image clustering parameters using H-optimus-0

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.