Vincent Bernard

Concurrent Stereotactic Body Radiation Therapy and KRAS Inhibition Synergistically Improve Pre-clinical Pancreatic Cancer Treatment

Tianyu Wang, L L W Wang, Jiaqian Xu, Youming Guo et autres

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most challenging cancers to treat due to the dismal survival rate, poor post-treatment outcome and profound resistance to a wide range of therapies. With mutant KRAS being a key driver, small molecule inhibitors …

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CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC

Kathleen M. McAndrews, Krishnan K. Mahadevan, Bingrui Li, Anaïs M Comptdaer et autres

Abstract Mutations in KRAS are a dominant driver of pancreatic ductal adenocarcinoma (PDAC), with about 50% of patients presenting with KRAS G12D mutations. Small molecule inhibitors targeting KRAS G12D suppress PDAC; however, the contribution of the tumor microenvironment (TME) to the sustained …

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Table S4 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Unique identifications via mass spectrometry.

Supplementary Figures S1-S12 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Fig. S1 | Cohort overview Fig. S2 | Study quality control overview Fig. S3 | Mass spectrometry performance across processing batches Fig. S4 | Intra-patient regional variation in TP53 and DCLK1 protein abundance Fig. S5 | Distinct protein abundance patterns across pancreatic …

Table S1 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Deep Visual Proteomics data.

Table S8 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Patient-sample relationship.

Table S3 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Biological pathway enrichment (GSEA).

Table S6 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

KRAS peptide mutations.

Data from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) evolves through precursors, yet the protein programs governing early progression remain poorly defined. We applied Deep Visual Proteomics (DVP)—integrating computational pathology, laser microdissection, and mass spectrometry (MS)—to profile normal ducts, acinar-to-ductal metaplasia (ADM), low-grade (LG) and high-grade …

Table S2 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Differential expression.

Table S5 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

ANOVA heatmap data.

Table S9 from AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Jimin Min, Lisa Schweizer, Gijs Zonderland, Benson Chellakkan Selvanesan et autres

Antibodies used in multiplex immunofluorescence.