Genomic landscape and phylogenetic insights of Burkholderia pseudomallei over two decades in southern China and its global surveillance
Rattachement africain : cn, hk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Melioidosis, caused by Burkholderia pseudomallei, is an endemic infectious disease with high mortality in tropical and subtropical regions. Large-scale epidemiological data remain insufficient in China, while comprehensive data integrating genomic epidemiology are rare worldwide. Herein, performed a retrospective analysis of 554 culture-confirmed melioidosis cases in southern China from 2003 to 2022. Genomic characteristics and their relationship with antimicrobial susceptibility and clinical characteristics were analyzed via whole genome sequencing. Core-genome SNP phylogenies were constructed from recombination-masked alignments and compared them with 3,573 publicly available global B. pseudomallei genomes to define their population structure and phylogeographic patterns. Melioidosis predominantly affected male patients (86.8%, 481/554) and those aged 45 -64 years (57.7%). Bacteremia (OR=5.91, p<0.001), diabetes mellitus (OR=2.27, p=0.008), and pulmonary infection (OR=2.26, p=0.005) were identified as risk factors for mortality. Antimicrobial susceptibility testing showed B. pseudomallei exhibited high in vitro susceptibility to imipenem (100%) and ceftazidime (99.6%). Pan-genome analysis confirmed chromosomal functional compartmentalization of the bipartite genome, and genome-wide association study identified high-confidence genetic markers (OR >3 or <0.33) significantly associated with mortality and bacteremia. Furthermore, global phylogenomic analysis identified 10 evolutionary clusters; Chinese isolates were significantly enriched in Cluster 1, a clade shared with Thai strains, and were phylogenetically distinct from Cluster 5, as predominantly composed of Australian isolates. In summary, this large-scale genomic and clinical analysis provides the most comprehensive overview of melioidosis in southern China. The genomic analysis highlighted substantial regional and global genetic diversity, and phylogeographic structuring of B. pseudomallei, underscoring the importance of continued genomic surveillance.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Genomic landscape and phylogenetic insights of <i>Burkholderia pseudomallei</i> over two decades in southern China and its global surveillance
- Date Crossref
- 30/06/2026
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Hainan Modern Women and Children's Hospital pays non établi dans la noticeÉtablissement de santé
-
Hainan Medical University pays non établi dans la noticeUniversité ou école supérieure
-
Chinese Academy of Medical Sciences & Peking Union Medical College China-Japan Friendship Hospital pays non établi dans la noticeUniversité ou école supérieure
-
China-Japan Friendship Hospital pays non établi dans la noticeÉtablissement de santé
-
Peking Union Medical College Hospital pays non établi dans la noticeÉtablissement de santé
-
Hainan General Hospital pays non établi dans la noticeÉtablissement de santé
-
Central South University pays non établi dans la noticeUniversité ou école supérieure
-
Integrated Chinese Medicine (China) pays non établi dans la noticeEntreprise
-
Beijing Chang'an Integrated Traditional Chinese and Western Medicine Hospital pays non établi dans la noticeÉtablissement de santé
-
Hainan 301 Hospital pays non établi dans la noticeÉtablissement de santé
-
Xian Yang Central Hospital pays non établi dans la noticeÉtablissement de santé
-
First People's Hospital of Nanning pays non établi dans la noticeÉtablissement de santé
Hainan Modern Women and Children's Hospital, Hainan Medical University et China-Japan Friendship Hospital — Chinese Academy of Medical Sciences & Peking Union Medical College, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.