Supplemental Figure 1 from Increased Glucose Availability Sensitizes Pancreatic Cancer to Macrophage-Targeting Immunotherapies

Le résumé fourni par la source

Supplemental Figure 1 - Immune competence is required to restrain pancreatic cancer growth in vivo. A.) Overall survival of mice with different immune backgrounds bearing identical KPC orthotopic pancreatic tumors. NSG mice lack functional T, B, and NK cells and have severely impaired innate immunity including macrophages. Athymic nude mice are deficient in T cells but retain functional innate immune cells including macrophages. C57Bl/6J mice possess an intact adaptive and innate immune system. Mice did not receive any therapy. Median survival was plotted with the Kaplan-Meier method and compared using the log-rank test. Gross photographs of spontaneous liver metastases and primary pancreatic tumor in NSG mice (B.) and normal liver with large primary pancreatic tumor in C57Bl/6J mice (C.).

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