Figure 1 from Increased Glucose Availability Sensitizes Pancreatic Cancer to Macrophage-Targeting Immunotherapies
Le résumé fourni par la source
High glucose is needed to maintain the metabolic profile of M1-like macrophages in vitro. OCR (A) and ECAR (B) of M1- and M2-like macrophages at differing glucose levels after 48 hours of treatment, assessed via Seahorse extracellular flux analysis. C, OCR of M0 macrophages in high- and low-glucose conditions. D, PCA of metabolites from M1- and M2-like macrophages grown in high and low glucose. E, LC/MS quantification of glycolytic and tricarboxylic acid cycle metabolites in M1- and M2-like macrophages at indicated glucose concentrations after 48 hours of treatment (top). Corresponding Western blot of iNOS and arginase levels at the time of metabolite harvest are also depicted (bottom), with gel lanes represented in line with the heatmap experimental groups above. ***, P < 0.001; ns, not significant.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Figure 1 from Increased Glucose Availability Sensitizes Pancreatic Cancer to Macrophage-Targeting Immunotherapies
- Date Crossref
- 23/06/2026
- Éditeur
- American Association for Cancer Research (AACR)
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.