Dynamic Changes in Midbrain–Striatal Association and Their Relationship With Levodopa‐Induced Dyskinesia in Parkinson’s Disease
Rattachement africain : kr, Éthiopie, pr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background The neurobiological pathology of levodopa‐induced dyskinesia (LID) remains unclear despite its prevalence. Emerging evidence suggests a critical interplay between dopaminergic and serotonergic systems in the development of LID. Objective This study aimed to investigate longitudinal changes in striatal and midbrain SBRs and their association with LID development, with exploratory evaluation of midbrain–striatal monoaminergic coupling. Methods A total of 169 drug‐naïve PD patients from the PPMI database were followed over four years. I‐123 FP‐CIT SPECT imaging was used to measure specific binding ratios (SBRs) in the caudate, putamen, and midbrain. Patients were categorized into LID and non‐LID groups at follow‐up. Interregional correlation analysis assessed the correlation between midbrain and striatal subregions. The impact of levodopa‐equivalent daily dose (LEDD) on correlation was also evaluated. Results The LID group exhibited significantly lower striatal SBRs at baseline and follow‐up compared to the non‐LID group. Midbrain SBRs declined more steeply in the LID group over time. In multivariable regression models adjusting for baseline clinical differences, the interaction between midbrain SBR and LID status for the 4‐year putamen SBR showed a trend‐level association ( p = 0.09, q = 0.15). The regression slope for the midbrain–putamen association was numerically higher in the LID group ( β = 1.1571) compared to the non‐LID group ( β = 0.5201) at 4 years. The midbrain‐to‐putamen ratio was higher in the LID group at baseline, indicating relatively preserved nonstriatal monoaminergic signal early in the disease course. After adjustment, LEDD and the midbrain × LEDD interaction were not independently associated with midbrain–putamen coupling. Conclusion Our findings suggest a dynamic pattern in which early relative preservation of nonstriatal monoaminergic signals, reflected by midbrain SBR changes, may accompany dopaminergic loss in patients who develop LID. Midbrain SBR should be interpreted as a proxy of monoaminergic integrity rather than a direct serotonergic biomarker. LID appears to mark a phenotype of accelerated nigrostriatal degeneration characterized by lower baseline and faster longitudinal decline of putaminal SBR. Midbrain–striatal coupling patterns may reflect secondary monoaminergic network changes associated with disease progression rather than a causal serotonergic mechanism.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Dynamic Changes in Midbrain–Striatal Association and Their Relationship With Levodopa‐Induced Dyskinesia in Parkinson’s Disease
- Date Crossref
- 01/01/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Bundang Jesaeng Hospital pays non établi dans la noticeÉtablissement de santé
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Seoul National University Bundang Hospital Department of Nuclear Medicine pays non établi dans la noticeÉtablissement de santé
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Hanlim Pharm (South Korea) pays non établi dans la noticeEntreprise
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Advanced Institute of Convergence Technology pays non établi dans la noticeStructure de recherche
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New Generation University College Éthiopie (code pays fourni par la source)Université ou école supérieure
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National University College pays non établi dans la noticeUniversité ou école supérieure
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Bundang Jesaeng General Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Graduate School of Convergence Science and Technology Department of Molecular Medicine and Biopharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Inc. Molim pays non établi dans la noticeEntreprise
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College of Medicine pays non établi dans la noticeUniversité ou école supérieure
Bundang Jesaeng Hospital, Department of Nuclear Medicine — Seoul National University Bundang Hospital et Hanlim Pharm (South Korea), avec 7 autres affiliations. Pays d’affiliation : Éthiopie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.