Supplementary Figure S14 from Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity

Le résumé fourni par la source

Experimental design for the induction of an exhausted phenotype in murine OT-I CD8+ T cells, relative expression of co-receptors, exhaustion markers, and TCF7 in murine CD8+ T cells at different time points of the exhaustion protocol, relative RNA expression of Ccl3, Cxcl13, and Entpd1 genes after one or three stimulations under hypoxia, relative proinflammatory cytokine production and secretion in singly-stimulated or continuously-stimulated T cells under hypoxia, relative expression of PRF1 and GZMB in murine CD8+ T cells after one or three stimulations upon hypoxic exposure, and killing capacity of challenged OT-I cells against B16-OVA melanoma cells.

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