Crosstalk Between Inflammation and Cellular Senescence in Osteoarthritis: Modulatory Actions of Olive Oil and Its Bioactive Compounds
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Le résumé fourni par la source
Osteoarthritis is a degenerative joint disorder characterized by progressive cartilage degradation, subchondral bone alterations, and persistent low-grade inflammation. Recent findings have identified a strong interplay between inflammation and cellular senescence in osteoarthritis. Chronic inflammatory signals promote the accumulation of senescent cells, while senescent cells amplify inflammatory pathways through their senescence-associated secretory phenotype (SASP). This bidirectional loop accelerates tissue damage by perpetuating oxidative stress, matrix degradation, and the release of proinflammatory mediators that reinforce the senescence process. Likewise, the biological activities of olive oil and its bioactive compounds, including monounsaturated and polyunsaturated fatty acids (PUFA), phenolic compounds (mainly ligstroside, oleocanthal, oleuropein, and hydroxytyrosol), squalene, phytosterols, vitamins (particularly vitamin E), and carotenoids, have attracted increased attention. These compounds may synergistically exert their effects through several interrelated mechanisms that influence both inflammatory and senescence pathways. They may modulate key signaling cascades, such as nuclear factor-κB (NF-κB), mitogen-activated protein kinases (MAPKs), and Toll-like receptors (TLRs), that drive the release of proinflammatory cytokines. Moreover, by attenuating SASP, olive oil compounds can potentially attenuate the vicious cycle between inflammation and senescence, slowing cartilage degradation and preserving joint function. Here, we synthesize current findings on the molecular mechanisms and clinical implications of bioactive compounds from olive oil, emphasizing their role in modulating both inflammation and senescence during osteoarthritis.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Crosstalk Between Inflammation and Cellular Senescence in Osteoarthritis: Modulatory Actions of Olive Oil and Its Bioactive Compounds
- Date Crossref
- 01/01/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Molise Department of Medicine and Health Sciences "V. Tiberio" pays non établi dans la noticeUniversité ou école supérieure
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University of Bari Aldo Moro pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal de Uberlândia pays non établi dans la noticeUniversité ou école supérieure
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Aristotle University of Thessaloniki Medical School pays non établi dans la noticeUniversité ou école supérieure
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University of Bari "Aldo Moro" Department of Pharmacy-Drug Sciences pays non établi dans la noticeUniversité ou école supérieure
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Italian Nutraceutical Society (SINut) pays non établi dans la noticeInstitution
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School of Medicine Interdisciplinary Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Federal University of Uberlandia Program of Post-Graduation in Health Science pays non établi dans la noticeUniversité ou école supérieure
Department of Medicine and Health Sciences "V. Tiberio" — University of Molise, University of Bari Aldo Moro et Universidade Federal de Uberlândia, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.