A Longitudinal Study of Antimicrobial Resistance in Oral Bacterial Isolates From Periodontitis Patients in Taiwan
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Le résumé fourni par la source
INTRODUCTION AND AIMS: The oral cavity harbours a complex microbial ecosystem that plays a critical role in periodontal health and disease. Despite growing concerns over antimicrobial resistance (AMR), long-term surveillance of antibiotic susceptibility in oral bacteria remains limited. This study aimed to assess the temporal trends in AMR among oral bacteria isolated from periodontitis patients in Taiwan over a 14-year period, with emphasis on genus-specific, Gram-specific, and sex-related patterns. METHODS: A total of 980 bacterial isolates were obtained from 466 periodontitis patients between 2008 and 2021. E-strip testing was performed for six antibiotics: amoxicillin, ciprofloxacin, clindamycin, metronidazole, minocycline, and amoxicillin-clavulanic acid. Susceptibility data were analysed by year and bacterial genus. RESULTS: Polymicrobial infections were predominant (98.1%), and resistance rates increased significantly over time, particularly for metronidazole (from 37.8% to 90.9%) and ciprofloxacin (from 33.1% to 51.5%). Streptococcus, Peptostreptococcus, and Capnocytophaga were more prevalent in females, while Neisseria, Fusobacterium, and Pseudomonas were more common in males. High resistance rates were observed in Neisseria, Escherichia, and Staphylococcus, with over 80% of some isolates resistant to multiple agents. CONCLUSION: Our findings reveal a progressive rise in AMR among oral bacteria and highlight the need for localized antibiotic stewardship in dentistry. This is the first long-term oral AMR surveillance study in Taiwan and offers a foundation for updating empirical treatment guidelines and informing public health policy. CLINICAL RELEVANCE: This study provides long-term, real-world AMR data for oral bacteria in Taiwan. The findings support more informed antibiotic selection in periodontal therapy and highlight the need to re-evaluate empirical use of metronidazole and fluoroquinolones in routine dental practice.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Longitudinal Study of Antimicrobial Resistance in Oral Bacterial Isolates From Periodontitis Patients in Taiwan
- Date Crossref
- 01/08/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kaohsiung Medical University Drug Development and Value Creation Research Center pays non établi dans la noticeUniversité ou école supérieure
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Kaohsiung Medical University Chung-Ho Memorial Hospital pays non établi dans la noticeÉtablissement de santé
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China Medical University pays non établi dans la noticeUniversité ou école supérieure
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Mackay Medical University Institute of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Taipei Medical University pays non établi dans la noticeUniversité ou école supérieure
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School of Dentistry pays non établi dans la noticeUniversité ou école supérieure
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College of Dental Medicine Anaerobic and Oral Microorganism Research Center pays non établi dans la noticeUniversité ou école supérieure
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College of Medicine Orthopaedic Research Center pays non établi dans la noticeUniversité ou école supérieure
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School of Chinese Medicine & Graduate Institute of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
Drug Development and Value Creation Research Center — Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital et China Medical University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.