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Relationship between negative-pressure ICU rooms and the risk of COVID-19-associated pulmonary aspergillosis: an ancillary analysis of the COVID-ICU cohort study
Louis Kreitmann, Anahita Rouzé, Charles‐Édouard Luyt, Keyvan Razazi, Muriel Fartoukh, Fabrice Bruneel, Laura Gouzien, Virginie Maxime, Christophe Le Terrier, Jean-Ralph Zahar, Hélène Behal, Saad Nseir, COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators, Matthieu Schmidt, David Hajage, Alexandre Demoule, Tài Pham, Alain Combes, Martin Dres, Saïd Lebbah, Antoine Kimmoun, Alain Mercat, Gaëtan Beduneau, Jessica Palmyre, Margot Prevost, Pierre Asfar, Francois Beloncle, Julien Demiselle, Arthur Pavot, Xavier Monnet, Christian Richard, Julien Mayaux, Alexandra Beurton, Richard Descamps, Aurélie Joret, Damien-Du Cheyron, Frédéric Pene, Jean‐Daniel Chiche, Mathieu Jozwiak, Paul Jaubert, Jean‐Pierre Bédos, Guillaume Voiriot, Marion Teulier, Clarisse Blayau, Erwen L’Her, Cécile Aubron, Laetitia Bodénes, Nicolas Ferrière, Johann Auchabie, Anthony-Le Meur, Sylvain Pignal, Thierry Mazzoni, Jean-Pierre Quenot, Pascal Andreu, Jean-Baptiste Roudau, Marie Labruyère, Sébastien Préau, Julien Poissy, Daniel Mathieu, Sarah Benhamida, Rémi Paulet, Nicolas Roucaud, Martial Thyrault, Florence Daviet, Sami Hraiech, Gabriel Parzy, Aude Sylvestre, Sébastien Jochmans, Anne-Laure Bouilland, Mehran Monchi, Marc- Danguy -des Déserts, Quentin Mathais, Gwendoline Rager, Pierre Pasquier, Reignier Jean, Seguin Amélie, Garret Charlotte, Canet Emmanuel, Jean Dellamonica, Clément Saccheri, Romain Lombardi, Yanis Kouchit, Sophie Jacquier, Armelle Mathonnet, Mai-Ahn Nay, Isabelle Runge, Frédéric Martino, Laure Flurin, Amélie Rollé, Michel Carles, Rémi Coudroy, Arnaud-W. Thille, Jean-Pierre Frat, Maeva Rodriguez, Pascal Beuret, Audrey Tientcheu, Arthur Vincent, Florian Michelin, Marie-Anne Melone, Maxime Gauzi, Arnaud Guilbert, Geoffrey Kouadri, Valérie Gissot, Stéphan Ehrmann, Charlotte-Salmon Gandonnière, Djlali Elaroussi, Agathe Delbove, Yannick Fédun, Julien Huntzinger, Eddy Lebas, Grâce Kisoka, Céline Grégoire, Stella Marchetta, Bernard Lambermont, Laurent Argaud, Thomas Baudry, Pierre-Jean Bertrand, Auguste Dargent, Christophe Guitton, Nicolas Chudeau, Mickaël Landais, Cédric Darreau, Alexis Ferre, Antoine Gros, Guillaume Lacave, Mathilde Neuville, Jérôme Devaquet, Guillaume Tachon, Richard Gallot, Riad Chelha, Arnaud Galbois, Anne Jallot, LuAuthorNameine -Chalumeau Lemoine, Khaldoun Kuteifan, Valentin Pointurier, Louise-Marie Jandeaux, Joy Mootien, Charles Damoisel, Benjamin Sztrymf, Juliette Chommeloux, Charles Edouard Luyt, Frédérique Schortgen, Leon Rusel, Camille Jung, Florent Gobert, Damien Vimpère, Lionel Lamhaut, Bertrand Sauneuf, L Charrier, Julien Calus, Isabelle Desmeules, Benoît Painvin, Jean-Marc Tadie, Vincent Castelain, Baptiste Michard, Jean-Étienne Herbrecht, Mathieu Baldacini, Nicolas Weiss, Sophie Demeret, Clémence Marois, Benjamin Rohaut, Pierre-Henri Moury, Anne-Charlotte Savida, Emmanuel Couadau, Mathieu Sèrié, Nica Alexandru, Cédric Bruel, Candice Fontaine, Sonia Garrigou, Juliette- Courtiade Mahler, Maxime Leclerc, Michel Ramakers, Pierre Garçon, Nicole Massou, Ly- Phacs -Van Vong, Juliane Sen, Nolwenn Lucas, Frank Chemouni, Annabelle Stoclin, Alexandre Avenel, Henri Faure, Angélie Gentilhomme, Sylvie Ricôme, Paul Abraham, Céline Monard, Julien Textoris, Thomas Rimmele, Florent Montini, Gabriel Lejour, Thierry Lazard, Isabelle Etienney, Younes Kerroumi, Dupuis Claire, Bereiziat Marine Coupez, Thouy François, Clémet Hoffmann, Nicolas Donat, V. Muller, Thibault Martinez, Audrey Jacquot, Matthieu Mattei, Bruno Levy, Ramin Ravan, Loïc Dopeux, Jean-Mathias Liteaudon, Delphine Roux, Brice Rey, Radu Anghel, Deborah Schenesse, Vincent Gevrey, Jermy Castanera, Philippe Petua, Benjamin Madeux, Otto Hartman, Michael Piagnerelli, Anne Joosten, Cindérella Noël, Patrick Biston, Thibaut Noël, Gurvan -L. E. Bouar, Messabi Boukhanza, Elsa Demarest, Marie-France Bajolet, Nathanaël Charrier, Audrey Quenet, Cécile Zylberfajn, Nicolas Dufour, Buno Mégarbane, Sqébastian Voicu, Nicolas Deye, Isabelle Malissin, François Legay, Matthieu Débarre, Nicolas Barbarot, Pierre Fillatre, Bertrand Delord, Thomas Laterrade, Tahar Saghi, Wilfried Pujol, Pierre‐Julien Cungi, Pierre Esnault, Mickaël Cardinale, Vivien-Hong-Tuan Ha, Grégory Fleury, Marie-Ange Brou, Daniel Zafimahazo, David Tran-Van, Patrick Avargues, Lisa Carenco, Nicolas Robin, Alexandre Ouali, Lucie Houdou, Christophe-Le Terrier, Noémie Suh, Steve Primmaz, Jérôme Pugin, Emmanuel Weiss, Tobias Gauss, Jean-Denis Moyer, Catherine Paugam-Burtz, Béatrice -La Combe, Rolland Smonig, Jade Violleau, Pauline Cailliez, Jonathan Chelly, Antoine Marchalot, Cécile Saladin, Christelle Bigot, Pierre-Marie Fayolle, Jules Fatséas, Amr Ibrahim, Dabor Résière, Rabih Hage, Clémentine Cholet, Marie Cantier, Pierre Trouiller, Philippe Montravers, Brice Lortat‐Jacob, Sebastien Tanaka, Alexy Tran‐Dinh, Jacques Duranteau, Anatole Harrois, Guillaume Dubreuil, Marie Werner, Anne Godiér, Sophie Hamada, Diane Zlotnik, Hélène Nougue, Armand Mekontso-Dessap, Guillaume Carteaux, Nicolas-De Prost, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Arié Attias, Charles-de Roquetaillade, Benjamin-G. Chousterman, Alexandre Mebazaa, Étienne Gayat, Marc Garnier, Emmanuel Pardo, Léa Satre-Buisson, Christophe Gutton, Élise Yvin, Clémence Marcault, Elie Azoulay, Michael Darmon, Nicolas Bonnet, Nathan Ebstein, Stèphane Gaudry, Y. Cohen, Hafid Ait-Oufella, Geoffroy Hariri, Tomas Urbina, Sandie Mazerand, Nicholas Heming, Francesca De Santi, Pierre Moine, Djillali Annane, Adrien Bouglé, Edris Omar, Aymeric Lancelot, Emmanuelle Bégot, Gaétan Plantefeve, Damien Contou, Hervé Mentec, Olivier Pajot, Stanislas Faguer, Olivier Cointault, Laurence Lavayssière, Marie‐Béatrice Nogier, Matthieu Jamme, Claire Pichereau, Jan Hayon, H. Outin, Francois Dépret, Maxime Coutrot, Maité Chaussard, Lucie Guillemet, Pierre Goffin, Romain Thouny, Julien Guntz, Laurent Jadot, Romain Persichini, Vanessa Jean-Michel, Hugues Georges, Thomas Cvaulier, Gaël Pradel, Marie-Hélène Hausermann, ThiMy -Hue Nguyen-Valat, Michel Boudinaud, Emmanuel Vivier, Sylvène Rosseli, Gaël Bourdin, Christian Pommier, Marc Vinclair, Simon Poignant, Sandrine Mons, Wulfran Bougouin, Franklin Bruna, Quentin Maestraggi, Christian Roth, Laurent Bitker, François Dhelft, Justine Bonnet-Chateau, Mathilde Filippelli, Tristan Morichau-Beauchant, Stéphane Thierry, Charlotte-Le Roy, Mélanie -Saint Jouan, Bruno Gonçalves, Aurélien Mazeraud, Matthieu Daniel, Tarek Sharshar, Cyril Cadoz, Rostane Gaci, Sébastien Gette, Guillaune Louis, Sophe-Caroline Sacleux, Marie‐Amélie Ordan, Aurélie Cravoisy, Marie Conrad, Guilhem Courte, Sébastien Gibot, Younès Benzidi, Claudia Casella, Laurent Serpin, Jean-Lou Setti, Marie-Catherine Besse, Anna Bourreau, Jérôme Pillot, Caroline Rivera, Camille Vinclair, Marie-Aline Robaux, Chloé Achino, Marie‐Charlotte Delignette, Tessa Mazard, Frédéric Aubrun, Bruno Bouchet, Aurélien Frerou, Laura Muller, Charlotte Quentin, Samuel Degoul, Xavier Stihle, Claude Sumian, Nicoletta Bergero, Bernard Lanaspre, Hervé Quintard, Eve-Marie Maiziere, Pierre-Yves Egreteau, Guillaume Leloup, Florin Berteau, Marjolaine Cottrel, Marie Bouteloup, Matthieu Jeannot, Quentin Blanc, Julien Saison, Isabelle Geneau, Romaric Grenot, Abdel Ouchike, Pascal Hazera, Anne-Lyse Masse, Suela Demiri, Corinne Vezinet, Ėlodie Baron, Déborah Benchetrit, A. Monsel, Grégoire Trebbia, Emmanuelle Schaack, Raphaël Lepecq, Mathieu Bobet, Christophe Vinsonneau, Thibault Dekeyser, Quentin Delforge, Imen Rahmani, Bérengère Vivet, Jonathan Paillot, Lucie Hierle, Claire Chaignat, Sarah Valette, Benoït Her, Jennifier Brunet, Mathieu Page, Fabienne Boiste, Anthony Collin, Florent Bavozet, A. Garin, Mohamed Dlala, Kais Mhamdi, Bassem Beilouny, Alexandra Lavalard, Severine Perez, Benoît Veber, Pierre‐Gildas Guitard, Philippe Gouin, Anna Lamacz, Fabienne Plouvier, Bertrand-P. Delaborde, Aïssa Kherchache, Amina Chaalal, Jean-Damien Ricard, Marc Amouretti, Santiago Freita-Ramos, Damien Roux, Jean-Michel Constantin, Mona Assefi, Marine Lecore, Agathe Selves, Florian Prevost, Christian Lamer, Ruiying Shi, Lyes Knani, Sébastien Pili‐Floury, Lucie Vettoretti, Michael Levy, Lucile Marsac, Stéphane Dauger, Sophie Guilmin‐Crépon, Jean-Baptiste Putegnat, Frédérique Bayle, Maya Perrou, Ghyslaine Thao, Guillaume Géri, Cyril Charron, Xavier Repessé, Antoine Vieillard-Baron, Mathieu Guilbart, Pierre-Alexandre Roger, Sébastien Hinard, Pierre-Yves Macq, Kevin Chaulier, Sylvie Goutte, Patrick Chillet, Anaïs Pitta, Barbara Darjent, Amandine Bruneau, Sigismond Lasocki, Maxime Leger, Soizic Gergaud, Pierre Lemarié, Nicolas Terzi, Carole Schwebel, Anaïs Dartevel, Louis-Marie Galerneau, Jean-Luc Diehl, Caroline Hauw-Berlemont, Nicolas Péron, Emmanuel Guérot, Abolfazl-Mohebbi Amoli, Michel Benhamou, Jean-Pierre Deyme, Olivier Andremont, Diane Lena, Julien Cady, Arnaud Causeret, Arnaud-De-La Chapelle, Christophe Cracco, Stéphane Rouleau, David Schnell, Cécile Lory, Thibault Chapelle, Vincent Bruckert, Julie Garcia, Abdlazize Sahraoui, Nathalie Abbosh, Caroline Bornstain, Pierre Pernet, Florent Poirson, Ahmed Pasem, Philippe Karoubi, Virginie Poupinel, Caroline Gauthier, François Bouniol, Philippe Feuchere, Anne Héron, Serge Carreira, Malo Emery, Anne-Le Floch, Luana Giovannangeli, Nicolas Herzog, Christophe Giacardi, Thibaut Baudic, Chloé Thill, Florence Tubach, Olivier Lesieur, Julie Noublanche
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Résumé fourni par la source
BACKGROUND: COVID-19-associated pulmonary aspergillosis (CAPA) has emerged as a serious complication of severe SARS-CoV-2 pneumonia in critically ill patients requiring invasive mechanical ventilation (IMV). Several host- and treatment-related risk factors have been identified, but the role of environmental factors-particularly ICU room air pressure-remains underexplored. METHODS: We conducted an ancillary analysis of the COVID-ICU study, a prospective multicenter cohort of COVID-19 patients admitted to ICUs in France, Belgium and Switzerland during the first wave of the pandemic. Our analysis included 1233 mechanically ventilated patients. We compared the cumulative incidence of probable invasive pulmonary aspergillosis (IPA), defined according to the 2024 Invasive-Fungal-Diseases-in-Adult-Patients-in-ICU (FUNDICU) consensus criteria, between patients isolated in negative-pressure rooms and those housed in neutral-pressure rooms. Secondary outcomes included the incidence of putative IPA, the incidence of putative IPA or Aspergillus colonization (both defined according to the AspICU algorithm), and the association between probable IPA occurrence and clinical outcomes. RESULTS: Probable IPA occurred significantly less frequently in patients isolated in negative-pressure rooms, compared to those in neutral-pressure rooms (2.0% vs. 4.8%; adjusted cause-specific hazard ratio [cHR] 0.44, 95%CI 0.21-0.90, p = 0.024). No significant between-group difference was observed in the incidence of putative IPA alone or in combination with Aspergillus colonization (1.3% vs. 2.1%, adjusted cHR 0.65, 95% CI 0.23-1.77, p = 0.4 and 3.3% vs. 5.8%, adjusted cHR 0.66, 95% CI 0.30-1.42, p = 0.29, respectively). The occurrence of probable IPA was associated with longer IMV duration and ICU length-of-stay (adjusted HR 0.45, 95% CI 0.27-0.76, p = 0.002 and 0.59, 95% CI 0.38-0.91, p = 0.017, respectively). CONCLUSION: In this large multicenter cohort of mechanically ventilated COVID-19 patients, isolation in negative-pressure ICU rooms was associated with a lower incidence of probable IPA, but the small event rate and potential confounders indicate this finding needs to be replicated and validated by other studies.
Sujets associés
Antifungal resistance and susceptibilityPneumothorax, Barotrauma, EmphysemaNosocomial Infections in ICU