Nathan Ebstein

Early red blood cell transfusion strategy in septic shock among patients with cancer: the TRANSPORT randomized controlled trial

Frédéric Pène, Clara Vigneron, Antoine Lafarge, Djamel Mokart et autres

fr (code pays fourni par la source)

Relationship between negative-pressure ICU rooms and the risk of COVID-19-associated pulmonary aspergillosis: an ancillary analysis of the COVID-ICU cohort study

Louis Kreitmann, Anahita Rouzé, Charles‐Édouard Luyt, Keyvan Razazi et autres

BACKGROUND: COVID-19-associated pulmonary aspergillosis (CAPA) has emerged as a serious complication of severe SARS-CoV-2 pneumonia in critically ill patients requiring invasive mechanical ventilation (IMV). Several host- and treatment-related risk factors have been identified, but the role of environmental factors-particularly ICU room air …

gb, fr, us, ch (code pays fourni par la source)

PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study

Lionel Tchatat Wangueu, Isaure Breteau, Matthieu Petit, Matthieu Schmidt et autres

Acute Kidney Injury (AKI) is common in patients admitted to the intensive care unit (ICU) for severe SARS-CoV-2 pneumonia and is associated with a worse prognosis. Mechanical ventilation has been identified as a risk factor for renal damage in COVID-19. However, few …

fr (code pays fourni par la source)

Routes of SARS-Cov2 transmission in the intensive care unit: A multicentric prospective study

Yacine Tandjaoui-Lambiotte, Alexandre Elabbadi, Boubaya Marouane, Sebastien L. Besset et autres

BACKGROUND: The risk of SARS-CoV-2 transmission to health care workers in intensive care units (ICU) and the contribution of airborne and fomites to SARS-CoV-2 transmission remain unclear. To assess the rate of air and surface contamination and identify risk factors associated with …

fr (code pays fourni par la source)

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos et autres

Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of …

fr, us, gb, au, nl, ch (code pays fourni par la source)

Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis

Keyvan Razazi, Charles‐Édouard Luyt, Guillaume Voiriot, Anahita Rouzé et autres

Abstract Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly related to Enterobacterales. Data regarding extended-spectrum beta-lactamase producing Enterobacterales (ESBL-E) VAP are scarce. …

fr, gp (code pays fourni par la source)

Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

Ilias Ι. Siempos, André C. Kalil, Drifa Belhadi, Viviane Cordeiro Veiga et autres

Background: Although immunomodulators have established benefit against the new coronavirus disease (COVID-19) in general, it is uncertain whether such agents improve outcomes without increasing the risk of secondary infections in the specific subgroup of previously immunocompromised patients. We assessed the effect of …

gr, us, fr, br (code pays fourni par la source)

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang et autres

International audience

fr, us, it, se, ir, ae, es, co, tr, br, lb, be, Égypte, pk, nl, pl, sa, il, gb, ch, cn, hk, dk, de (code pays fourni par la source)

Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19

Christophe Le Terrier, Thaïs Walter, Saïd Lebbah, David Hajage et autres

BACKGROUND: Previous retrospective research has shown that maintaining prone positioning (PP) for an average of 40 h is associated with an increase of survival rates in intubated patients with COVID-19-related acute respiratory distress syndrome (ARDS). This study aims to determine whether a …

ch, fr (code pays fourni par la source)

Effect of weight-adjusted intermediate-dose versus fixed-dose prophylactic anticoagulation with low-molecular-weight heparin on venous thromboembolism among noncritically and critically ill patients with COVID-19: the COVI-DOSE trial, a multicenter, randomised, open-label, phase 4 trial

Stéphane Zuily, Benjamin Lefèvre, Olivier Sanchez, Ombeline Empis de Vendin et autres

Background: Venous thromboembolism is a major complication of coronavirus disease 2019 (COVID-19). We hypothesized that a weight-adjusted intermediate dose of anticoagulation may decrease the risk of venous thromboembolism COVID-19 patients. Methods: In this multicenter, randomised, open-label, phase 4, superiority trial with blinded …

fr, us, mc (code pays fourni par la source)

Clinical relevance and prognostic value of renal Doppler in acute decompensated precapillary pulmonary hypertension

Jérémie Pichon, Anne Roche, Charles Fauvel, Athénaïs Boucly et autres

AIMS: We aim to evaluate the clinical relevance and the prognostic value of arterial and venous renal Doppler in acute decompensated precapillary pulmonary hypertension (PH). METHODS AND RESULTS: The renal resistance index (RRI) and the Doppler-derived renal venous stasis index (RVSI) were …

fr (code pays fourni par la source)

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang et autres

Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. …

fr, us, it, se, ir, ae, es, co, tr, br, lb, be, Égypte, pk, nl, pl, sa, il, gb, ch, cn, hk, dk, de (code pays fourni par la source)