Prevalence and associated factors of prediabetes among adults living with HIV receiving dolutegravir-based antiretroviral therapy in Zambia
Rattachement africain : Afrique du Sud, Zambie, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
As people living with HIV (PLHIV) experience longer survival globally, including in Zambia, the widespread adoption of dolutegravir-based antiretroviral therapy (ART) as the preferred first-line regimen has been accompanied by growing recognition of metabolic complications such as prediabetes as an emerging public health concern. However, evidence on the burden and determinants of prediabetes within routine HIV care settings in sub-Saharan Africa, including Zambia, remains limited. This study aimed to determine the prevalence of prediabetes and its associated factors among adults receiving dolutegravir-based ART at Livingstone University Teaching Hospital to inform early screening, prevention, and integration of metabolic disease management into HIV care. We conducted a cross-sectional study between 20 November 2025 and 19 December 2025 using secondary data from adults (≥ 18 years) receiving dolutegravir-based ART at Livingstone University Teaching Hospital, Zambia. Sociodemographic, behavioral, clinical, and laboratory variables were abstracted from medical records. Prediabetes was defined as fasting glucose 5.6–6.9 mmol/L. Logistic regression was used to identify factors associated with prediabetes, and odds ratios (ORs) with 95% confidence intervals (CIs) were reported. Among 322 participants (median age 47 years; 63.3% female), the prevalence of prediabetes was 17.7% (95% CI: 13.7–22.3). Higher BMI (aOR: 1.09, 95% CI 1.01–1.17; p = 0.014) and total cholesterol (aOR :1.69, 95% CI 1.11–2.58; p = 0.014) were independently associated with prediabetes. Age, sex, smoking, and alcohol use were not significantly associated, while physical activity showed a borderline association (aOR: 1.79, 95% CI 0.91–3.52; p = 0.089). Nearly one in five adults living with HIV receiving dolutegravir-based ART had prediabetes. Higher BMI and total cholesterol were key correlates. Integrating routine fasting glucose monitoring alongside targeted lifestyle counseling may support earlier detection and prevention of diabetes progression. Prospective studies are needed to confirm causality and assess long-term outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prevalence and associated factors of prediabetes among adults living with HIV receiving dolutegravir-based antiretroviral therapy in Zambia
- Date Crossref
- 24/05/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Livingstone Hospital Afrique du Sud (code pays fourni par la source)Établissement de santé
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Mulungushi University Zambie (code pays fourni par la source)Université ou école supérieure
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Zambia Forestry College Zambie (code pays fourni par la source)Université ou école supérieure
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University Teaching Hospital Department of Internal Medicine Lusaka, Zambie (code pays fourni par la source)Établissement de santé
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Livingstone College pays non établi dans la noticeUniversité ou école supérieure
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Livingstone Center for Prevention and Translational Science Zambie (code pays fourni par la source)Organisation à but non lucratif
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School of Medicine and Health Sciences Department of Public Health Zambie (pays nommé en fin d’affiliation)Université ou école supérieure
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Kitwe Teaching Hospital Department of Internal Medicine Kitwe Teaching Hospital, Zambie (pays nommé en fin d’affiliation)Établissement de santé
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Department of Health Economics Zambie (pays nommé en fin d’affiliation)Institution
Livingstone Hospital (Afrique du Sud), Mulungushi University (Zambie) et Zambia Forestry College (Zambie), avec 6 autres affiliations. Pays d’affiliation : Afrique du Sud, Zambie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.