Nutritional Supplementation Combined with Exercise for Musculoskeletal Health in Women: A Systematic Review and Meta-Analysis Evaluating Proteins, Amino Acids, and Creatine across Reproductive Stages
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Le résumé fourni par la source
Background: Women experience progressive musculoskeletal deterioration across reproductive stages, with accelerated changes during the menopausal transition. Exercise provides established benefits, but the additive effects of nutritional supplementation strategies, including proteins, amino acids, and related compounds such as creatine, remain uncertain. Previous systematic reviews focused on older adults aged 65 years and above, leaving a knowledge gap regarding women facing unique metabolic challenges related to reproductive hormones. Therefore, this systematic review and meta-analysis was conducted to evaluate whether nutritional supplementation combined with exercise enhances muscle mass, strength, and bone health outcomes in women across reproductive stages, with particular attention to the menopausal transition. Methods: Eight databases were searched from inception to July 2025: CINAHL, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials, Embase, PsycINFO, MEDLINE/PubMed, Scopus, and Web of Science. We included randomized controlled trials examining nutritional supplementation combined with exercise in women across reproductive stages. Interventions comprised whole proteins, amino acids, amino acid derivatives, or protein-derived peptides administered with structured exercise programs. Comparators included exercise alone or a placebo plus exercise. Primary outcomes were muscle mass measures. Secondary outcomes included muscle strength, bone health parameters, body composition, and adverse events. Random-effects meta-analyses calculated Hedges' g with 95% confidence intervals (CIs). Results: =0.430). No increase in adverse events was observed. Conclusions: Current evidence does not support robust additive effects of nutritional supplementation on muscle mass or bone health when combined with exercise in women across reproductive stages. Selective upper-body strength improvements were observed, particularly in studies using creatine supplementation. Exercise alone provides reliable musculoskeletal health benefits. Given the heterogeneity of supplement types examined, future research should employ longer intervention durations (≥12 months) with site-specific bone measurements and conduct head-to-head comparisons of specific supplement types.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Nutritional Supplementation Combined with Exercise for Musculoskeletal Health in Women: A Systematic Review and Meta-Analysis Evaluating Proteins, Amino Acids, and Creatine across Reproductive Stages
- Date Crossref
- 16/04/2026
- Éditeur
- Ivyspring International Publisher
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wan Fang Hospital pays non établi dans la noticeÉtablissement de santé
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Taipei Medical University Cochrane Taiwan pays non établi dans la noticeUniversité ou école supérieure
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China Medical University Department of Nursing pays non établi dans la noticeUniversité ou école supérieure
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China Medical University Hospital pays non établi dans la noticeÉtablissement de santé
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National Chiayi University pays non établi dans la noticeUniversité ou école supérieure
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Purdue University West Lafayette pays non établi dans la noticeUniversité ou école supérieure
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College of Nursing Post-Baccalaureate Program in Nursing pays non établi dans la noticeUniversité ou école supérieure
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School of Nursing pays non établi dans la noticeUniversité ou école supérieure
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Teachers College Department of Physical Education pays non établi dans la noticeUniversité ou école supérieure
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School of Gerontology and Long-Term Care pays non établi dans la noticeUniversité ou école supérieure
Wan Fang Hospital, Cochrane Taiwan — Taipei Medical University et Department of Nursing — China Medical University, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.