Neuroendocrine Pathways in Skin Health and Homeostasis: A Systematic Review

Le résumé fourni par la source

The skin is increasingly recognized as a neuroendocrine organ that continuously communicates with the nervous system, linking cutaneous biology with overall wellness. Despite growing interest in the skin-brain axis, there remains limited synthesis of interventional strategies targeting neuropeptides and neurotransmitters to improve skin health. This systematic review aimed to evaluate the current evidence on neuropeptide- and neurotransmitter-based interventions in dermatology, with a focus on mood-related pathways and cutaneous outcomes. A systematic search of PubMed (January 2015-September 2025) was performed, including interventional studies investigating key neuroendocrine mediators in skin disease and regeneration. A total of 68 studies met inclusion criteria, the majority of which were preclinical, with a smaller proportion of randomized controlled trials. Melatonin, substance P modulation and oxytocin demonstrated the most consistent evidence across anti-inflammatory, reparative and psychodermatologic outcomes. Collectively, these findings position neurohormonal signaling as an emerging therapeutic target in dermatology, with potential applications spanning both disease management and aesthetic medicine.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.