A Novel Approach to Determining Bone Loss Through Serum Uric Acid Levels: A Retrospective Multicenter Cohort Analysis
Rattachement africain : tr, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Osteoporosis has a rising global incidence and social burden. Serum uric acid’s dual roles in oxidative stress and inflammation may influence bone health, but findings are inconsistent and require further research. This study aimed to evaluate the relationship between SUA levels and osteoporosis in a multicenter cohort obtained from different regions of Türkiye. Methods: This multi-center retrospective study included 3280 individuals, postmenopausal women and men aged 45 and older, from 16 centers in Türkiye. Individuals were excluded if they recently consumed alcohol, had severe renal dysfunction, certain hormonal or mineral disorders, specific medications, or certain menopausal statuses. Bone mineral density (BMD) at the hip and lumbar spine was measured using dual-energy X-ray absorptiometry (DXA), and participants were classified as normal or having osteopenia or osteoporosis based on T-score thresholds. Results: Overall, 34.8% were male, and 65.2% were female. For the lumbar spine, 36.8% had osteopenia, and 13.5% had osteoporosis; similarly, for the total hip, 40.8% had osteopenia, and 7.9% had osteoporosis. ROC analysis identified a threshold of 3.9 mg/dL serum uric acid (SUA) (AUC 0.374; p < 0.001), which was positively associated with both lumbar and total hip BMD. Osteoporosis rates were higher in patients with SUA < 3.9 mg/dL compared to those with SUA ≥ 3.9 mg/dL at the lumbar spine (29.1% vs. 14.2%, p < 0.001) and total hip sites (23.6% vs. 15.9%, p = 0.003). After adjustment for potential confounders, SUA was a significant independent predictor of osteoporosis in the lumbar spine (OR 0.70; p < 0.001) and the hip (OR 0.80; p < 0.001). Conclusions: Serum uric acid levels are inversely linked to bone mineral density and osteoporosis risk, indicating a potential role in bone health. However, due to study limitations, causal relationships remain unproven, and further research is needed.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Novel Approach to Determining Bone Loss Through Serum Uric Acid Levels: A Retrospective Multicenter Cohort Analysis
- Date Crossref
- 15/04/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Istanbul Medipol University pays non établi dans la noticeUniversité ou école supérieure
-
Kütahya Dumlupınar Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
-
Kutahya Saglik Bilimleri Universitesi pays non établi dans la noticeUniversité ou école supérieure
-
Ondokuz Mayıs University pays non établi dans la noticeUniversité ou école supérieure
-
Dicle University pays non établi dans la noticeUniversité ou école supérieure
-
Erzincan Binali Yıldırım University pays non établi dans la noticeUniversité ou école supérieure
-
Kayseri Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
-
Izmir Atatürk Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
-
Siirt Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
-
Education Training And Research pays non établi dans la noticeOrganisation à but non lucratif
-
Recep Tayyip Erdoğan University pays non établi dans la noticeUniversité ou école supérieure
-
Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
Istanbul Medipol University, Kütahya Dumlupınar Üniversitesi et Kutahya Saglik Bilimleri Universitesi, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.