Cerebellum Development in Neonates and Association With Preterm Birth: MR Fingerprinting Study
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Le résumé fourni par la source
Purpose: Cerebellar maturation is critical for neonatal development and is often disrupted during preterm birth.This study used magnetic resonance (MR) fingerprinting to quantify age-related cerebellar changes and determine the specific impact of prematurity. Materials and Methods:This retrospective study included 31 neonates (22 preterm and 9 term; 17 males; mean gestational age, 249.0 ± 20.7 days) who underwent brain MRI, including 2D multi-slice MR fingerprinting with 7 minutes 5 seconds scan time at termequivalent age.The T1 and T2 relaxation times were measured in the middle cerebellar peduncle, dentate nucleus, and cerebellar cortex using MR fingerprinting-derived T1 and T2 maps.Group differences and correlations with postmenstrual age were assessed using independent t-tests and Pearson's correlation analysis.Results: Preterm neonates had longer T1 and T2 relaxation times in the middle cerebellar peduncle, dentate nucleus, and cerebellar cortex than did term neonates.In the middle cerebellar peduncle, T1 times were 1918 ± 88 ms vs. 1760 ± 68 ms (p < 0.001), and T2 times were 103 ± 8 ms vs. 97 ± 4 ms (p < 0.05).In the dentate nucleus, the T1 times were 2316 ± 174 ms vs. 1976 ± 144 ms (p < 0.001), and the T2 times were 141 ± 18 ms vs. 122 ± 11 ms (p < 0.05).In the cerebellar cortex, T1 was 2460 ± 98 ms vs. 2192 ± 127 ms (p < 0.001), and T2 was 152 ± 14 ms vs. 127 ± 23 ms (p < 0.05).Both T1 and T2 times negatively correlated with postmenstrual age across all regions (r ranged from -0.761 to -0.617, all p < 0.001).Prolonged relaxation times were associated with prematurity (odds ratio range: 1.03 to 1.16, p < 0.05). Conclusion:The MR fingerprinting-derived T1 and T2 relaxation times showed developmental changes with postmenstrual age and were higher in preterm neonates, indicating immaturity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cerebellum Development in Neonates and Association With Preterm Birth: MR Fingerprinting Study
- Date Crossref
- 01/01/2026
- Éditeur
- XMLink
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ulsan College Department of Radiology and Research Institute of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Asan Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Ulsan pays non établi dans la noticeUniversité ou école supérieure
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The Catholic University of Korea Seoul St. Mary's Hospital pays non établi dans la noticeÉtablissement de santé
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Catholic University of Korea pays non établi dans la noticeUniversité ou école supérieure
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Hankuk University of Foreign Studies Department of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Dwight School pays non établi dans la noticeUniversité ou école supérieure
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College of Medicine Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Siemens Healthineers Ltd. pays non établi dans la noticeEntreprise
Department of Radiology and Research Institute of Radiology — Ulsan College, Asan Medical Center et University of Ulsan, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.