White matter microstructure and hemispheric asymmetry alterations in adults who smoke: a connectome-based analysis
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INTRODUCTION: Cigarette smoking poses a pervasive health risk increasingly recognized for its impact on the nervous system, yet its effects on brain structure and organization remain incompletely understood. This study examined how smoking addiction influences white matter (WM) microstructure and the architecture of structural brain networks in adults. METHODS: We used diffusion tensor imaging to compare fractional anisotropy between participants who smoke (n = 122) and non-smoking control participants (n = 55) to detect WM abnormalities. Whole-brain structural connectomes were constructed, with connections categorized by fiber length. Network features quantified included degree centrality and hemispheric asymmetry. Adaptive Best-Subset Selection method was applied to identify WM connections that may serve as biomarkers for distinguishing individuals who smoke from those who do not. RESULTS: Participants who smoke showed widespread WM alterations in pathways related to reward valuation, habit formation, and craving, along with abnormalities in both short- and medium-range connections. Reduced rightward asymmetry in the cuneus indicated lateralized structural changes possibly linked to cue processing in nicotine dependence. Discriminative connections involved orbitofrontal, sensorimotor, and visual regions, underscoring how smoking reshapes brain networks supporting reward valuation, motor control, and cue reactivity. CONCLUSIONS: Nicotine dependence is associated with extensive alterations in WM microstructure and network organization, including reduced hemispheric asymmetry. These findings suggest that smoking affects structural connectivity in circuits involved in emotional regulation and reward-related memory. IMPLICATIONS: This study enhances our understanding of how nicotine dependence reshapes WM networks, potentially impairing communication within circuits sustaining addictive behaviors, and provide insights into how smoking alters brain structure and connectivity.
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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- White matter microstructure and hemispheric asymmetry alterations in adults who smoke: a connectome-based analysis
- Date Crossref
- 25/03/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Science and Technology of China pays non établi dans la noticeUniversité ou école supérieure
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Hefei University of Technology pays non établi dans la noticeUniversité ou école supérieure
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Hunan Normal University Key Laboratory of Applied Statistics and Data Science pays non établi dans la noticeUniversité ou école supérieure
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Changsha Normal University pays non établi dans la noticeUniversité ou école supérieure
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Jiaozuo University pays non établi dans la noticeUniversité ou école supérieure
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Henan Polytechnic University Magnetic Resonance Department pays non établi dans la noticeUniversité ou école supérieure
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School of Management Department of Statistics and Finance pays non établi dans la noticeUniversité ou école supérieure
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School of Mathematics and Statistics pays non établi dans la noticeUniversité ou école supérieure
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The Second People’s Hospital of Jiaozuo Magnetic Resonance Department pays non établi dans la noticeÉtablissement de santé
University of Science and Technology of China, Hefei University of Technology et Key Laboratory of Applied Statistics and Data Science — Hunan Normal University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.