Remote Ischemic Conditioning for Acute Ischemic Stroke: The RICAIS Randomized Clinical Trial
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
AIMS: Preclinical studies have shown that remote ischemic conditioning (RIC) has a neuroprotective effect; however, the findings of clinical studies are inconsistent. This study aimed to show the effect of RIC on acute ischemic stroke while considering its severity at baseline. METHODS: We enrolled 79 patients with ischemic stroke who had National Institute of Health Stroke Scale (NIHSS) scores of 5-20 within 48 h after stroke onset and randomized them into the RIC [n = 43] and control groups [n = 36]. The intervention was performed using an inflatable cuff on one lower extremity. In the RIC group, each treatment consisted of four cycles of 5 min cuff inflation and deflation. The treatment was repeated once daily for at least three days. Based on the NIHSS score, the patients were divided into three groups: mild (NIHSS 5-9), moderate (NIHSS 10-14), and severe (NIHSS 15-20). The primary outcome was a good functional outcome at 90 days, defined as a modified Rankin Scale score of 0-1 in the mild group, 0-2 in the moderate group, and 0-3 in the severe group. RESULTS: Among the 79 patients (mean age, 65.0 years, 40 women), 7 (16.3%) in the RIC group and 8 (22.2%) in the control group had good functional outcomes (odds ratio, 0.73 [95% confidence interval, 0.29-1.82]; P = 0.502). The incidences of major adverse cardiovascular events, aspiration pneumonia, and serious adverse events were similar in both the groups. CONCLUSION: Although this study may have been underpowered, RIC initiated within 48 h of stroke onset did not seem to improve the functional outcomes in acute ischemic stroke.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Remote Ischemic Conditioning for Acute Ischemic Stroke: The RICAIS Randomized Clinical Trial
- Date Crossref
- 01/07/2026
- Éditeur
- Japan Atherosclerosis Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Suita Municipal Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Tokyo Women's Medical University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Iwate Prefectural Central Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Osaka Prefectural Medical Center pays non établi dans la noticeÉtablissement de santé
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Saitama Red Cross Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Showa General Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Osaka National Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Jikei University School of Medicine Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Kyorin University Department of Stroke and Cerebrovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Tokyo Women's Medical University Adachi Medical Center pays non établi dans la noticeÉtablissement de santé
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Nippon Medical School pays non établi dans la noticeUniversité ou école supérieure
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Kumamoto University Hospital Department of Neurology pays non établi dans la noticeÉtablissement de santé
Department of Neurology — Suita Municipal Hospital, Department of Neurology — Tokyo Women's Medical University et Department of Neurology — Iwate Prefectural Central Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.