Disseminated Mycobacterium tilburgii infection complicated by pulmonary non-tuberculosis mycobacteriosis in a patient with acquired immunodeficiency syndrome: A case report and literature review
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
RATIONALE: Mycobacterium tilburgii is the causative agent of disseminated non-tuberculosis mycobacterial infections in individuals who are immunocompromised, including those with human immunodeficiency virus infection. Owing to its non-culturable nature, identification of M. tilburgii relies solely on genetic analysis, making reports of M. tilburgii infections rare. We report a case of disseminated M. tilburgii infection complicated by a mixed pulmonary non-tuberculosis mycobacterial infection in a patient with acquired immunodeficiency syndrome. PATIENT CONCERNS: A male patient in his 40s, diagnosed with human immunodeficiency virus, was admitted with suspected disseminated non-tuberculosis mycobacterial infection based on initial laboratory findings and mycobacterial testing. Mycobacterium intracellulare and Mycobacterium kansasii were detected in the respiratory specimens. Acid-fast staining of the blood and bone marrow samples was positive; however, no bacterial growth was observed in the cultures. Genetic analysis of the blood and bone marrow samples revealed the presence of M. tilburgii. DIAGNOSES: The patient was diagnosed with disseminated M. tilburgii infection, accompanied by a mixed pulmonary non-tuberculosis mycobacterial infection. Enterococcus faecium, Candida parapsilosis, and Candida glabrata were also detected in blood cultures. OUTCOMES: Despite ongoing treatment with antibiotics and antifungals, the patient died of septic shock. LESSONS: Mycobacterium tilburgii is non-culturable; therefore, when acid-fast bacilli are detected in smear microscopy without subsequent culture growth, clinicians should consider the possibility of M. tilburgii infection and conduct thorough investigations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Disseminated Mycobacterium tilburgii infection complicated by pulmonary non-tuberculosis mycobacteriosis in a patient with acquired immunodeficiency syndrome: A case report and literature review
- Date Crossref
- 13/03/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tokai University Hospital Department of Laboratory Technology pays non établi dans la noticeÉtablissement de santé
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Tokai University Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Omuta hospital pays non établi dans la noticeÉtablissement de santé
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Japan Anti Tuberculosis Association pays non établi dans la noticeInstitution
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National Hospital Organization Omuta National Hospital Department of Respiratory Medicine pays non établi dans la noticeÉtablissement de santé
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The Research Institute of Tuberculosis Department of Mycobacterium Reference and Research pays non établi dans la noticeStructure de recherche
Department of Laboratory Technology — Tokai University Hospital, Department of Internal Medicine — Tokai University et Omuta hospital, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.