Ustilago maydis disrupts carbohydrate signaling networks to induce hypertrophy in host cells
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Le résumé fourni par la source
Ustilago maydis infection in maize causes hypertrophic leaf tumors; however, the underlying mechanisms driving this excessive cell growth are unknown. In this study, we identify Hap1 (hypertrophy-associated protein 1) as an effector and virulence factor that regulates mesophyll cell hypertrophy. Using CRISPR-Cas9 mutagenesis, we demonstrate that Hap1 contributes to endoreduplication and starch accumulation in infected tissues. Transcriptomics revealed Hap1-dependent upregulation of starch biosynthesis and cell cycle genes, as well as suppression of plant defense. This links Hap1 to metabolic and cell cycle reprogramming, and immune suppression. To identify the target of Hap1 that drives metabolic reprogramming, we investigated its interaction with ZmSnRK1α in maize. We found that Hap1 interferes with the phosphorylation of SnRK1 substrates and that two Hap1-interacting effectors, Hip1 and Hip2, enhance its protein stability. We conclude that Hap1 contributes to the reprogramming of maize metabolism and cell cycle, as well as mesophyll cell hypertrophy, by modulating the SnRK1 signaling pathway to regulate starch biosynthesis and host defense responses.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Ustilago maydis disrupts carbohydrate signaling networks to induce hypertrophy in host cells
- Date Crossref
- 20/02/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Cologne Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS) pays non établi dans la noticeUniversité ou école supérieure
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Cluster of Excellence on Plant Sciences pays non établi dans la noticeStructure de recherche
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Max Planck Institute for Plant Breeding Research Protein Mass Spectrometry pays non établi dans la noticeStructure de recherche
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North Dakota State University Department of Plant Pathology pays non établi dans la noticeUniversité ou école supérieure
Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS) — University of Cologne, Cluster of Excellence on Plant Sciences et Protein Mass Spectrometry — Max Planck Institute for Plant Breeding Research, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.