Albumin-bound paclitaxel drives a cytotoxic CD8+ T cell enriched immune microenvironment in triple negative breast cancer
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Le résumé fourni par la source
Background Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential and resistance to conventional therapies, representing a significant clinical challenge. Although nano albumin-bound paclitaxel (nab-PTX) has demonstrated generally good treatment effect, the mechanisms underlying its enhanced therapeutic performance, particularly its potential immunomodulatory effects, remain unclear. Methods Using both in vitro and in vivo TNBC models, we investigated the immunomodulatory effects of nab-PTX. Specifically, we evaluated its ability to induce immunogenic cell death (ICD), activate dendritic cells (DCs) via the cGAS-STING signaling pathway, and influence CD8 + T cell recruitment and infiltration within the tumor microenvironment. Results Treatment with nab-PTX induced ICD in TNBC cells was associated with enhanced activation of DCs through the cGAS-STING pathway. This activation was accompanied by improved antigen presentation and a significant increase in intratumoral CD8 + T cell infiltration. Collectively, these immune alterations suggest that nab-PTX contributes to a more immunologically active tumor microenvironment, characterized by heightened T cell mediated immune engagement. Conclusion Our study indicate that, beyond its direct cytotoxic effects, nab-PTX may exert anti-tumor activity in TNBC through modulation of the tumor immune microenvironment. By inducing ICD and promoting DCs activation, nab-PTX appears to support CD8 + T cell recruitment, thereby potentially enhancing immune mediated tumor regression. This immunologically supportive role of nab-PTX highlights its potential value in strategies aimed at improving the efficacy of chemotherapy based or immunotherapy combined treatments in TNBC.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Albumin-bound paclitaxel drives a cytotoxic CD8+ T cell enriched immune microenvironment in triple negative breast cancer
- Date Crossref
- 18/02/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guiyang Medical University pays non établi dans la noticeUniversité ou école supérieure
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Guizhou Cancer Hospital pays non établi dans la noticeÉtablissement de santé
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Affiliated Hospital of Guizhou Medical University Department of Oncology pays non établi dans la noticeÉtablissement de santé
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Guizhou Center for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Affiliated Cancer Hospital of Guizhou Medical University Department of Oncology pays non établi dans la noticeUniversité ou école supérieure
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School of Biology & Engineering pays non établi dans la noticeUniversité ou école supérieure
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Engineering Center of Cellular Immunotherapy of Guizhou Province pays non établi dans la noticeInstitution
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Key Laboratory of Infectious Immunity and Antibody Engineering of Guizhou Province pays non établi dans la noticeStructure de recherche
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Key Laboratory of Microbio and Infectious Disease Prevention & Control of Guizhou pays non établi dans la noticeStructure de recherche
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School of Public Health pays non établi dans la noticeUniversité ou école supérieure
Guiyang Medical University, Guizhou Cancer Hospital et Department of Oncology — Affiliated Hospital of Guizhou Medical University, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.