Cytosolic Delivery of a Bithiophene Derivative via Polymersomes Kills Trypanosoma cruzi Amastigotes and Modulates the Inflammatory Response
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Le résumé fourni par la source
High Resolution Image Download MS PowerPoint Slide Chagas disease, caused by the protozoan Trypanosoma cruzi, is an infectious illness that progresses through acute, indeterminate, and chronic phases. The acute phase often presents mild symptoms, followed by an asymptomatic indeterminate phase. In some cases, the disease advances to chronic Chagas cardiomyopathy, driven by sustained inflammation. Current treatments, benznidazole and nifurtimox, have limited efficacy in this stage and are associated with significant toxicity, highlighting the need for better therapies. PEG- b -PPS loaded with BTAc, exhibited favorable physicochemical properties, including high stability and an average size of 120 nm, suitable for efficient uptake by phagocytic cells such as macrophages. BTAc -loaded polymersomes showed enhanced efficacy against intracellular amastigotes of three T. cruzi strains (CL Brener, Brazil and Y) with IC 50 values of 6.17, 24.01, and 30.68 μg/mL, respectively. The formulation simultaneously reduced proinflammatory cytokines to basal levels, suggesting an immunomodulatory potential. Importantly, Förster Resonance Energy Transfer analysis confirmed that BTAc -loaded polymersomes remain intact upon cellular uptake, escape the endosomal compartment, and release their payload directly into the cytosol, which is the intracellular niche where amastigotes persist during chronic infection. These findings underscore the potential of this nanocarrier system as an innovative approach that combines targeted antitrypanosomal therapy with enhanced immunomodulation, offering a promising strategy for the treatment of chronic Chagas disease.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Cytosolic Delivery of a Bithiophene Derivative via Polymersomes Kills <i>Trypanosoma cruzi</i> Amastigotes and Modulates the Inflammatory Response
- Date Crossref
- 14/02/2026
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Estadual de Maringá pays non établi dans la noticeUniversité ou école supérieure
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Chemistry of Life Processes Institute Department of Biomedical Engineering pays non établi dans la noticeStructure de recherche
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University of Virginia pays non établi dans la noticeUniversité ou école supérieure
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Rede de Química e Tecnologia pays non établi dans la noticeOrganisation à but non lucratif
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Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos pays non établi dans la noticeInstitution
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Northwestern University pays non établi dans la noticeUniversité ou école supérieure
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NanoSTAR Institute Department of Biomedical Engineering pays non établi dans la noticeStructure de recherche
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Programa de Pós-graduação em Química pays non établi dans la noticeInstitution
Universidade Estadual de Maringá, Department of Biomedical Engineering — Chemistry of Life Processes Institute et University of Virginia, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.